Isha Singh

TL;DR: Using a make-on-demand library that contains hundreds-of-millions of molecules, structure-based docking was used to identify compounds that, after synthesis and testing, are shown to interact with AmpC β-lactamase and the D4 dopamine receptor with high affinity.

TL;DR: In this article, crystal structures of 16-mer duplexes with two nonstandard nucleobases (Z, 6-amino-5-nitro-2(1H)-pyridone and P, 2aminoimidazo[1,2-a]-1,3,5-triazin-4(8H)one) were designed to form a Z:P pair with a standard edge on the Watson-Crick geometry, but joined by rearranged hydrogen bond donor and acceptor groups.

TL;DR: The ability of standard duplexes to accommodate multiple and consecutive Z:P pairs is consistent with the ability of natural polymerases to biosynthesize those pairs, implying that the GACTZP synthetic genetic system can explore the entire expanded sequence space that additional nucleotides create, a major step forward in this area of synthetic biology.

TL;DR: The MRGPRX family of receptors as mentioned in this paper is a family of mas-related G-protein-coupled receptors that have evolved relatively recently and are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity reactions.

TL;DR: The discovery of two new DNA-like systems that appear to support molecular recognition with the same proficiency as standard Watson-Crick DNA, however, these both violate size complementarity (big pairs with small), retaining hydrogen bond complementarity as their only specificity principle.