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Andy Protter
Publications - 4
Citations - 229
Andy Protter is an academic researcher. The author has contributed to research in topics: Stromal cell & Bone marrow. The author has an hindex of 3, co-authored 4 publications receiving 228 citations.
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Journal ArticleDOI
Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo.
Rongrong Ge,Vaishali Rajeev,Partha S. Ray,Edmund C. Lattime,Susan R. Rittling,Satya Medicherla,Andy Protter,Alison Murphy,Jit Chakravarty,Sundeep Dugar,George F. Schreiner,Nicola Barnard,Michael Reiss +12 more
TL;DR: TGF-β type I receptor kinase inhibitors hold promise as novel therapeutic agents for metastatic breast cancer after testing their effects on two murine mammary carcinoma cell lines in vitro and in vivo.
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Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.
Aaron N. Nguyen,Elizabeth G. Stebbins,Margaret Henson,Gilbert O'Young,Sun J. Choi,Diana Quon,Debby Damm,Mamatha Reddy,Jing Y. Ma,Edwin Haghnazari,Ann M. Kapoun,Satyanarayana Medicherla,Andy Protter,George F. Schreiner,Noriyoshi Kurihara,Judy Anderson,G. David Roodman,G. David Roodman,Tony A. Navas,Linda S. Higgins +19 more
TL;DR: It is demonstrated that SCIO-469 treatment can suppress factors in the bone marrow microenvironment to inhibit MM cell proliferation and adhesion and also to alleviate osteolytic activation in MM.
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Inhibition of p38α MAPK Reduces Tumor Burden, Prevents the Development of Myeloma Bone Disease, and Increases Survival in the 5T2 and 5T33 Murine Models of Myeloma.
Karin Vanderkerken,Satya Medicherla,Les Coulton,Benjamin Van Camp,Andy Protter,Linda S. Higgins,Eline Menu,Peter I. Croucher +7 more
TL;DR: Targeting p38 α MAPK with SCIO-469 is associated with an anti-myeloma effect, which indirectly prevents the development of myeloma bone disease.
Journal ArticleDOI
SCIO-469, a Potent and Selective Inhibitor of p38a MAPK, Normalizes the Bone Marrow Microenvironment and Inhibits Multiple Myeloma Cell Proliferation in In Vitro and In Vivo Models.
Aaron N. Nguyen,Mamatha M. Reddy,Margaret Henson,Elizabeth G. Stebbins,Gilbert O'Young,Jing Y. Ma,Edwin Haghnazari,Ann M. Kapoun,Satya Medicherla,Andy Protter,Tony A. Navas,Linda S. Higgins +11 more
TL;DR: SCIO-469 is a suppressor of the BM microenvironment and an effective inhibitor of MM cell proliferation in vitro and in vivo, and p38 inhibition significantly inhibited the increase in MM tumor volume.