A
Andy T. Long
Researcher at University of Hamburg
Publications - 18
Citations - 1523
Andy T. Long is an academic researcher from University of Hamburg. The author has contributed to research in topics: Factor XII & Coagulation. The author has an hindex of 14, co-authored 18 publications receiving 1152 citations. Previous affiliations of Andy T. Long include Case Western Reserve University & University of Oklahoma Health Sciences Center.
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Journal ArticleDOI
Host DNases prevent vascular occlusion by neutrophil extracellular traps
Miguel Jiménez-Alcázar,Chandini Rangaswamy,Rachita Panda,Josephine Bitterling,Yashin J. Simsek,Andy T. Long,Rostyslav Bilyy,Veit Krenn,Christoph Renné,Thomas Renné,Thomas Renné,Stefan Kluge,Ulf Panzer,Ryushin Mizuta,Hans Georg Mannherz,Daisuke Kitamura,Martin Herrmann,Markus Napirei,Tobias A. Fuchs,Tobias A. Fuchs +19 more
TL;DR: A noncanonical mechanism for vascular occlusion based on neutrophil extracellular traps (NETs), DNA fibers released by neutrophils during inflammation are reported and provide dual host protection against deleterious effects of intravascular NETs.
Journal ArticleDOI
Contact system revisited: an interface between inflammation, coagulation, and innate immunity.
TL;DR: This review summarizes how the contact system acts as the cross‐road of inflammation, coagulation, and innate immunity.
Journal Article
Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis
Doris M. Benbrook,Andy T. Long +1 more
TL;DR: This review will discuss autophagy and how it is integrated with proteasomal degradation and UPR to govern cell fate through restoration of cellular homeostasis or default into the apoptotic cell death pathway.
Journal ArticleDOI
Plasma contact system activation drives anaphylaxis in severe mast cell–mediated allergic reactions
Anna Sala-Cunill,Anna Sala-Cunill,Jenny Björkqvist,Riccardo Senter,Riccardo Senter,Mar Guilarte,Victoria Cardona,Moisés Labrador,Katrin F. Nickel,Katrin F. Nickel,Lynn M. Butler,Lynn M. Butler,Olga Luengo,Parvin Kumar,Linda Labberton,Andy T. Long,Antonio Di Gennaro,Ellinor Kenne,Anne Jämsä,Thorsten Krieger,Hartmut Schlüter,Tobias A. Fuchs,Tobias A. Fuchs,Stefanie Flohr,Ulrich Hassiepen,Frederic Cumin,Keith R. McCrae,Coen Maas,Evi X. Stavrou,Thomas Renné,Thomas Renné +30 more
TL;DR: In this paper, a plasma protease cascade, the factor XII-driven contact system, critically contributes to the pathogenesis of anaphylaxis in both murine models and human subjects.
Journal ArticleDOI
The plasma contact system, a protease cascade at the nexus of inflammation, coagulation and immunity.
Henri Weidmann,Laura Heikaus,Andy T. Long,Clément Naudin,Hartmut Schlüter,Thomas Renné,Thomas Renné +6 more
TL;DR: The contact system is a potent procoagulant and proinflammatory plasma protease cascade that is initiated by binding ("contact")-induced, auto-activation of factor XII zymogen, and its regulation by endogenous and exogenous inhibitors, and roles in disease states are reviewed.