A
Aneta Balcerczyk
Researcher at University of Łódź
Publications - 64
Citations - 2774
Aneta Balcerczyk is an academic researcher from University of Łódź. The author has contributed to research in topics: Epigenetics & Chromatin. The author has an hindex of 22, co-authored 55 publications receiving 2241 citations. Previous affiliations of Aneta Balcerczyk include Baker IDI Heart and Diabetes Institute & Hong Kong Environmental Protection Department.
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Journal ArticleDOI
Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail
Daniella Brasacchio,Jun Okabe,Christos Tikellis,Aneta Balcerczyk,Prince George,Emma Baker,Anna C. Calkin,Michael Brownlee,Mark E. Cooper,Mark E. Cooper,Assam El-Osta +10 more
TL;DR: Transient hyperglycemia mediates persistent gene-activating events attributed to changes in epigenetic information and indicates that the active transcriptional state of the NFκB-p65 gene is linked with persisting epigenetic marks, which appear to occur as a result of effects of the methyl-writing and methyl-erasing histone enzymes.
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Antioxidative and prooxidative effects of quercetin on A549 cells
TL;DR: The effects of quercetin on A549 cells in in vitro culture were found to be complex and include both antioxidant effects and induction of oxidative stress due to formation of reactive oxygen species in the extracellular medium.
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Epigenetic phenomena linked to diabetic complications
TL;DR: The findings of the DCCT–EDIC and UKPDS epidemiological studies suggest that early exposure to hyperglycemia predisposes individuals to the development of diabetic complications, a phenomenon referred to as metabolic memory or the legacy effect.
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Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
Luciano Pirola,Aneta Balcerczyk,Richard W. Tothill,Izhak Haviv,Antony Kaspi,Sebastian Lunke,Mark Ziemann,Tom C. Karagiannis,Stephen Tonna,Adam Kowalczyk,Bryan Beresford-Smith,Geoff Macintyre,Ma Kelong,Zhang Hongyu,Jingde Zhu,Assam El-Osta +15 more
TL;DR: It is uncovered that hyperglycemia-mediated induction of genes and pathways associated with endothelial dysfunction occur through modulation of acetylated H3K9/K14 inversely correlated with methyl-CpG content.
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Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells
Jun Okabe,Christian Orlowski,Aneta Balcerczyk,Christos Tikellis,Merlin C. Thomas,Mark E. Cooper,Assam El-Osta +6 more
TL;DR: It is found that transient hyperglycemia regulates the expression of proinflammatory genes in vascular endothelial cells in vitro and the persistent increase in glucose-induced gene expression in the aorta of nondiabetic mice.