S
Sebastian Lunke
Researcher at University of Melbourne
Publications - 83
Citations - 2678
Sebastian Lunke is an academic researcher from University of Melbourne. The author has contributed to research in topics: Medicine & Exome sequencing. The author has an hindex of 20, co-authored 63 publications receiving 1785 citations. Previous affiliations of Sebastian Lunke include Royal Children's Hospital & Baker IDI Heart and Diabetes Institute.
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Journal ArticleDOI
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer
Matthew K.H. Hong,Geoff Macintyre,David C. Wedge,Peter Van Loo,Keval M. Patel,Sebastian Lunke,Ludmil B. Alexandrov,Clare Sloggett,Marek Cmero,Francesco Marass,Dana W.Y. Tsui,Stefano Mangiola,Andrew Lonie,Haroon Naeem,Nikhil Sapre,Pramit M. Phal,Natalie Kurganovs,Xiaowen Chin,Michael Kerger,Anne Y. Warren,David E. Neal,Vincent Gnanapragasam,Nitzan Rosenfeld,John Pedersen,Andrew Ryan,Izhak Haviv,Anthony J. Costello,Niall M. Corcoran,Christopher M. Hovens +28 more
TL;DR: The precise direction of metastatic spread is revealed across four lethal prostate cancer patients using whole-genome and ultra-deep targeted sequencing of longitudinally collected primary and metastatic tumours and analysis of mutations associated with metastasis reveals an enrichment of TP53 mutations.
Journal ArticleDOI
Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
Luciano Pirola,Aneta Balcerczyk,Richard W. Tothill,Izhak Haviv,Antony Kaspi,Sebastian Lunke,Mark Ziemann,Tom C. Karagiannis,Stephen Tonna,Adam Kowalczyk,Bryan Beresford-Smith,Geoff Macintyre,Ma Kelong,Zhang Hongyu,Jingde Zhu,Assam El-Osta +15 more
TL;DR: It is uncovered that hyperglycemia-mediated induction of genes and pathways associated with endothelial dysfunction occur through modulation of acetylated H3K9/K14 inversely correlated with methyl-CpG content.
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Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture
Fanny Grillet,Elsa Bayet,Elsa Bayet,Elsa Bayet,Olivia Villeronce,Olivia Villeronce,Olivia Villeronce,Luke Zappia,Ebba Louise Lagerqvist,Ebba Louise Lagerqvist,Ebba Louise Lagerqvist,Sebastian Lunke,Emmanuelle Charafe-Jauffret,Kym Pham,Christina Mølck,Nathalie Rolland,Jean-François Bourgaux,Michel Prudhomme,Claire Philippe,Sophie Bravo,Jean Christophe Boyer,Lucile Canterel-Thouennon,Graham R. Taylor,Arthur Hsu,Jean-Marc Pascussi,Jean-Marc Pascussi,Jean-Marc Pascussi,Frédéric Hollande,Julie Pannequin,Julie Pannequin,Julie Pannequin +30 more
TL;DR: The existence of patient-derived colorectal CTCs that bear all the functional attributes of CSCs are directly demonstrated, and RNA sequencing analyses strikingly demonstrate that drug metabolising pathways represent the most upregulated feature among CTC lines in comparison with primary CRC cells grown under similar conditions.
Journal ArticleDOI
Feasibility of ultra-rapid exome sequencing in critically ill infants and children with suspected monogenic conditions in the Australian public health care system
Sebastian Lunke,Stefanie Eggers,Meredith Wilson,Chirag Patel,Christopher P. Barnett,Jason Pinner,Sarah A. Sandaradura,Michael Buckley,Emma I. Krzesinski,Michelle G. de Silva,Gemma R Brett,Kirsten Boggs,David Mowat,Edwin P. Kirk,Edwin P. Kirk,Lesley C. Adès,Lauren S. Akesson,David J. Amor,David J. Amor,Samantha Ayres,Anne Baxendale,Sarah Borrie,Alessandra Bray,Natasha J Brown,Cheng Yee Chan,Cheng Yee Chan,Belinda Chong,Corrina Cliffe,Martin B. Delatycki,Matthew S. Edwards,George Elakis,Michael C Fahey,Andrew Fennell,Lindsay F. Fowles,Lyndon Gallacher,Megan Higgins,Megan Higgins,Katherine B. Howell,Katherine B. Howell,Lauren Hunt,Lauren Hunt,Matthew F. Hunter,Kristi J. Jones,Sarah R. B. King,Smitha Kumble,Sarah Lang,Maelle Le Moing,Alan Ma,Dean Phelan,Michael C.J. Quinn,Anna E. Richards,Christopher M. Richmond,Jessica R. Riseley,Jonathan Rodgers,Rani Sachdev,Simon Sadedin,Luregn J. Schlapbach,Janine Smith,Amanda Springer,Natalie B Tan,Tiong Yang Tan,Suzanna L. Temple,Christiane Theda,Christiane Theda,Anand Vasudevan,Susan M. White,Alison Yeung,Ying Zhu,Melissa Martyn,Stephanie Best,Tony Roscioli,Tony Roscioli,John Christodoulou,Zornitza Stark +73 more
TL;DR: This study suggests feasibility of ultra-rapid genomic testing in critically ill pediatric patients with suspected monogenic conditions in the Australian public health care system, however, further research is needed to understand the clinical value of such testing, and the generalizability of the findings to other health care settings.
Journal ArticleDOI
Does genomic sequencing early in the diagnostic trajectory make a difference? A follow-up study of clinical outcomes and cost-effectiveness.
Zornitza Stark,Deborah Schofield,Deborah Schofield,Melissa Martyn,Luke Rynehart,Rupendra N. Shrestha,Khurshid Alam,Khurshid Alam,Sebastian Lunke,Tiong Yang Tan,Clara Gaff,Susan M. White +11 more
TL;DR: The case for the early use of genomic testing in the diagnostic trajectory is strengthened, and laboratory policy on periodic WES data reanalysis can be guided, and the cost and benefits of cascade testing and reproductive service use are guided.