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Angela R. Hess
Researcher at Northwestern University
Publications - 23
Citations - 5575
Angela R. Hess is an academic researcher from Northwestern University. The author has contributed to research in topics: Vasculogenic mimicry & Melanoma. The author has an hindex of 17, co-authored 23 publications receiving 5221 citations. Previous affiliations of Angela R. Hess include Roy J. and Lucille A. Carver College of Medicine & University of Iowa.
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Journal ArticleDOI
Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry
Andrew J. Maniotis,Robert Folberg,Angela R. Hess,Elisabeth A. Seftor,Lynn M. G. Gardner,Jacob Pe'er,Jeffrey M. Trent,Paul S. Meltzer,Mary J.C. Hendrix +8 more
TL;DR: It is suggested that aggressive melanoma cells may generate vascular channels that facilitate tumor perfusion independent of tumor angiogenesis, providing a biomechanical explanation for the generation of microvessels in vitro.
Journal ArticleDOI
Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma
TL;DR: The gene expression profile of aggressive cutaneous and uveal melanoma cells resembles that of an undifferentiated, embryonic-like cell as mentioned in this paper, which has been termed "vasculogenic mimicry".
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Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness.
Jolanta M. Topczewska,Lynne-Marie Postovit,Naira V. Margaryan,Anthony Sam,Angela R. Hess,William W. Wheaton,Brian J. Nickoloff,Jacek Topczewski,Mary J.C. Hendrix +8 more
TL;DR: It is shown that aggressive melanoma cells secrete Nodal (a potent embryonic morphogen) and consequently can induce ectopic formation of the embryonic axis, and thus may be involved in melanoma pathogenesis.
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Expression and functional significance of VE-cadherin in aggressive human melanoma cells: role in vasculogenic mimicry
Mary J.C. Hendrix,Elisabeth A. Seftor,Paul S. Meltzer,Lynn M. G. Gardner,Angela R. Hess,Dawn A. Kirschmann,Gina C. Schatteman,Richard E.B. Seftor +7 more
TL;DR: Down-regulation of VE-cadherin expression in the aggressive melanoma cells abrogated their ability to form vasculogenic networks and directly tested the hypothesis that VE -caderin is critical in melanoma vasculogen mimicry.
Journal ArticleDOI
Lysyl Oxidase Regulates Breast Cancer Cell Migration and Adhesion through a Hydrogen Peroxide–Mediated Mechanism
Stacey L. Payne,Ben Fogelgren,Angela R. Hess,Elisabeth A. Seftor,Elizabeth L. Wiley,Sheri F. T. Fong,Katalin Csiszar,Mary J.C. Hendrix,Dawn A. Kirschmann +8 more
TL;DR: The results suggest that LOX facilitates migration and cell-matrix adhesion formation in invasive breast cancer cells through a hydrogen peroxide-mediated mechanism involving the FAK/Src signaling pathway, and show the need to target LOX for treatment of aggressive breast cancer.