Katalin Csiszar

TL;DR: Reduction of lysyl oxidase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and PI3K activity, impeded malignancy, and lowered tumor incidence, and data show how collagenCrosslinking can modulate tissue fibrosis and stiffness to force focal adhesion, growth factor signaling and breast malignancies.

TL;DR: The exclusion of five genes and the identification of the first mutations responsible for the development of PXE in a gene encoding a protein associated with multidrug resistance (ABCC6) are reported.

TL;DR: The multifunctional properties of lysyl oxidase (LOX) and the recent discovery of three novel members of this amine oxidase family, LOX-like (LOXL), LOXL2, and LOXL3, indicate the possibility that these varied functions are performed in both intracellular and extracellular environments by individual novelMembers of the LOX amine-oxidase family.

TL;DR: It is shown that lysyl‐oxidase‐like 2 and 3 (LOXL2 and LOXL3) interact and cooperate with Snail to downregulate E‐cadherin expression, establishing a direct link between LO XL2 and Snail in carcinoma progression.

TL;DR: It is demonstrated that the mRNA expression of LOX and other LOX family members [lysyl oxidase-like (LOXL), LOXL2, LOXL3, and LOXL4] was observed only in breast cancer cells with a highly invasive/ metastatic phenotype but not in poorly invasive/nonmetastatic breast cancer Cells.