Giacomo Dell'Antonio

TL;DR: Inhibition of autophagy by genetic means or chloroquine treatment leads to robust tumor regression and prolonged survival in pancreatic cancer xenografts and genetic mouse models, and drugs that inactivate this process may have a unique clinical utility in treating pancreatic cancers and other malignancies with a similar dependence on Autophagy.

TL;DR: The findings point to uromodulin as a therapeutic target for lowering blood pressure and preserving renal function and the relevance of this mechanism in humans is demonstrated by showing that pharmacological inhibition of NKCC2 was more effective in lowering blood pressured patients who are homozygous for UMOD promoter risk variants than in other hypertensive patients.

TL;DR: PTX3 represents a novel acute-phase reactant produced at sites of active vasculitis, and did not correlate with CRP levels in Vasculitis patients.

TL;DR: Intraplantar administration of oATP into inflamed paws significantly relieved inflammatory pain and the antinociceptive effect of o ATP was independent of the immune-cell recruitment.

TL;DR: Defects in the homeostatic response to cell death/remodeling events, revealed by enhanced levels of PTX3, could be implicated in preeclampsia.