Showing papers by "Angelo C. Pinto published in 1997"
TL;DR: T-DCTN demonstrated a significant hypoglycemic activity in alloxan-induced diabetic rats but not in normal rats, at oral doses of 25 and 50 mg/kg body weight.
Abstract: trans-Dehydrocrotonin (t-DCTN), a 19-nor-clerodane diterpene isolated from the bark of Croton cajucara Benth. (Euphorbiaceae) demonstrated a significant hypoglycemic activity in alloxan-induced diabetic rats but not in normal rats, at oral doses of 25 and 50 mg/kg body weight. The drug also effectively lowered the blood sugar levels in glucose fed normal rats. The hypoglycemic effect of t-DCTN was almost comparable to that produced by glibenclamide (2 mg/kg), a clinically useful drug. The results indicate the antihyperglycemic potential of t-DCTN.
55 citations
TL;DR: In this paper, a comparative study of the composition of commercial copaiba oils was carried out by high resolution gas chromatography (HRGC) and high resolution GC-MS analysis.
Abstract: Copaiba oil is a resin extracted from the trunk of trees of Copaifera species which grow in Brazil where it is widely used in popular medicine as an anti-inflammatory, antiseptic anti-bactericidal, diuretic, dermatological, expectorant, and anti-infective The comparative study of the composition of commercial copaiba oils was carried out by high resolution gas chromatography (HRGC) and high resolution gas chromatography-mass spectrometry (HRGC-MS) analysis The commercial oils were compared with authentic oils, collected from the southeast and northern regions of Brazil Sixteen commercial oils were analysed and two of them revealed adulterations with fatty acids Using the chromatographic profile of authentic copaiba species oils, it is possible to analyse commercial oils and determine the authenticity of these materials
52 citations
TL;DR: Two new diterpenoid acids, Magdalenic acid and bismagdalenae, have been isolated from the hexane extract of the Brazilian plant Vellozia magdalensae (Velloziaceae) as discussed by the authors.
19 citations
TL;DR: McCarthy and Duthie as mentioned in this paper used a reversed-phase semipreparative high pressure liquid chromatography to identify five acidic diterpenes in the hexane extract of Vellozia flavicans.
Abstract: The acidic compounds of the hexane extract of Vellozia flavicans could be selectively isolated when submitted to McCarthy and Duthie chromatography on a potassium hydroxide impregnated silica gel flash column followed by purification by C-18 reversed-phase semipreparative high pressure liquid chromatography. This method allowed the characterization of five acidic diterpenes, two of which could only be identified by co-injection of the appropriate standards owing to their very low concentration in the extract. © 1997 by John Wiley & Sons, Ltd.
9 citations
TL;DR: The main objectives of as mentioned in this paper are to present and discuss the facts that lead to the conception of JBCS in 1987, its birth in 1990 and the stages traveled until its consolidation.
Abstract: The main objectives of this article are to present and discuss the facts that lead to the conception of JBCS in 1987, its birth in 1990 and the stages traveled until its consolidation. The community's of Chemistry participation and the role of the Sub-program of Chemistry and Chemical Engineering of PADCT are emphasized.
6 citations
5 citations