A
Anika Benzin
Researcher at University of Hamburg
Publications - 4
Citations - 488
Anika Benzin is an academic researcher from University of Hamburg. The author has contributed to research in topics: Embryoid body & Published Erratum. The author has an hindex of 3, co-authored 4 publications receiving 366 citations.
Papers
More filters
Journal ArticleDOI
Human Engineered Heart Tissue: Analysis of Contractile Force
Ingra Mannhardt,K. Breckwoldt,David Letuffe-Brenière,Sebastian Schaaf,Herbert Schulz,Christiane Neuber,Anika Benzin,Tessa Werner,Alexandra Eder,Thomas G. Schulze,Birgit Klampe,Torsten Christ,Marc N. Hirt,Norbert Huebner,Alessandra Moretti,Thomas Eschenhagen,Arne Hansen +16 more
TL;DR: Systematic contractility analysis reveals that EHTs replicated canonical response to physiological and pharmacological regulators of inotropy, membrane- and calcium-clock mediators of pacemaking, modulators of ion-channel currents, and proarrhythmic compounds with unprecedented precision.
Journal ArticleDOI
Differentiation of cardiomyocytes and generation of human engineered heart tissue
K. Breckwoldt,David Letuffe-Brenière,Ingra Mannhardt,Thomas G. Schulze,Bärbel M. Ulmer,Tessa Werner,Anika Benzin,Birgit Klampe,Marina Reinsch,Sandra D. Laufer,Aya Shibamiya,Maksymilian Prondzynski,Giulia Mearini,Dennis Schade,Sigrid Fuchs,Christiane Neuber,Elisabeth Krämer,Umber Saleem,Mirja L Schulze,Marita L. Rodriguez,Thomas Eschenhagen,Arne Hansen +21 more
TL;DR: This protocol describes the differentiation of cardiomyocytes from hiPSCs; standardized generation of defined embryoid bodies, growth factor and small-molecule-based cardiac differentiation; and standardizedgeneration of EHTs.
Journal ArticleDOI
Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
Ingra Mannhardt,Umber Saleem,Anika Benzin,Thomas G. Schulze,Birgit Klampe,Thomas Eschenhagen,Arne Hansen +6 more
TL;DR: It is demonstrated, with the example of the hERG channel inhibitor E-4031, that the human EHT system replicates drug responses on contraction kinetics of the human heart, indicating it to be a promising tool for cardiac drug safety screening.
Journal ArticleDOI
Author Correction: Differentiation of cardiomyocytes and generation of human engineered heart tissue.
K. Breckwoldt,David Brenière-Letuffe,Ingra Mannhardt,Thomas G. Schulze,Bärbel M. Ulmer,Tessa Werner,Anika Benzin,Birgit Klampe,Marina Reinsch,Sandra D. Laufer,Aya Shibamiya,Maksymilian Prondzynski,Giulia Mearini,Dennis Schade,Sigrid Fuchs,Christiane Neuber,Elisabeth Krämer,Umber Saleem,Mirja L Schulze,Marita L. Rodriguez,Thomas Eschenhagen,Arne Hansen +21 more
TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.