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Mirja L Schulze
Researcher at University of Hamburg
Publications - 9
Citations - 511
Mirja L Schulze is an academic researcher from University of Hamburg. The author has contributed to research in topics: Medicine & Regenerative medicine. The author has an hindex of 6, co-authored 8 publications receiving 322 citations.
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Journal ArticleDOI
Differentiation of cardiomyocytes and generation of human engineered heart tissue
K. Breckwoldt,David Letuffe-Brenière,Ingra Mannhardt,Thomas G. Schulze,Bärbel M. Ulmer,Tessa Werner,Anika Benzin,Birgit Klampe,Marina Reinsch,Sandra D. Laufer,Aya Shibamiya,Maksymilian Prondzynski,Giulia Mearini,Dennis Schade,Sigrid Fuchs,Christiane Neuber,Elisabeth Krämer,Umber Saleem,Mirja L Schulze,Marita L. Rodriguez,Thomas Eschenhagen,Arne Hansen +21 more
TL;DR: This protocol describes the differentiation of cardiomyocytes from hiPSCs; standardized generation of defined embryoid bodies, growth factor and small-molecule-based cardiac differentiation; and standardizedgeneration of EHTs.
Journal ArticleDOI
Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes
Bärbel M. Ulmer,Andrea Stoehr,Mirja L Schulze,Sajni Patel,Marjan Gucek,Ingra Mannhardt,Sandra Funcke,Elizabeth Murphy,Thomas Eschenhagen,Arne Hansen +9 more
TL;DR: Contractile work contributes to metabolic maturation of hiPSC-CMs, which exhibited the principal ability to use glucose, lactate, and fatty acids as energy substrates irrespective of culture format.
Journal ArticleDOI
Human Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers.
Marc D Lemoine,Tobias Krause,Jussi T. Koivumäki,Jussi T. Koivumäki,Maksymilian Prondzynski,Mirja L Schulze,Evaldas Girdauskas,Stephan Willems,Arne Hansen,Thomas Eschenhagen,Torsten Christ +10 more
TL;DR: EHT from hiPSC-CMs shows a lower repolarization reserve than human LV working myocardium and could thereby serve as a sensitive and specific human-based model for repolarized studies and arrhythmia, similar to Purkinje fibers.
Journal ArticleDOI
Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner
Eva Querdel,Marina Reinsch,L. Castro,Deniz Köse,Andrea Bähr,Andrea Bähr,Svenja Reich,Birgit Geertz,Bärbel M. Ulmer,Mirja L Schulze,Marc D Lemoine,Tobias Krause,Marta Lemme,Jascha Sani,Aya Shibamiya,Tim Stüdemann,Maria Köhne,Constantin V. von Bibra,Nadja Hornaschewitz,Simon Pecha,Yusuf Nejahsie,Ingra Mannhardt,Torsten Christ,Hermann Reichenspurner,Arne Hansen,Nikolai Klymiuk,Nikolai Klymiuk,Markus Krane,Christian Kupatt,Thomas Eschenhagen,Florian Weinberger +30 more
TL;DR: In this article, human engineered heart tissue (EHT) transplantation represents a potential regenerative strategy for patients with heart failure and has been successful in preclinical models. Clinical...
Journal ArticleDOI
Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue
Marta Lemme,Ingke Braren,Maksymilian Prondzynski,Maksymilian Prondzynski,Bülent Aksehirlioglu,Bärbel M. Ulmer,Mirja L Schulze,Djemail Ismaili,Christian Meyer,Arne Hansen,Torsten Christ,Marc D Lemoine,Thomas Eschenhagen +12 more
TL;DR: A high vulnerability to tachycardia of optically tachypaced hiPSC-CMs in EHT is demonstrated and the effective termination by ryanodine receptor stabilization, sodium or hERG potassium channel inhibition is demonstrated.