Anis Khusro Mir

TL;DR: It is established that the cardiovascular response to 8-OH-DPAT in the rat is centrally mediated and point to the putative 5-HT1A receptor as the key site involved.

TL;DR: A conformational study of four 5-HT1A (serotonin) receptor ligands led to the definition of a pharmacophore and a three-dimensional map of the 5- HT1A antagonist recognition site and these models were used to design new compounds and successfully predict their potency, stereospecificity, and selectivity.

TL;DR: Results suggest that an interaction with 5‐HT1A receptors is the basis of the anxiolytic‐like activity of MDL 73005EF, however, its mechanism of action is clearly different from that of buspirone, possibly reflecting a greater selectivity for the 5‐ HT1A receptor located presynaptically on central 5‐hydroxytryptaminergic neurones.

TL;DR: It is concluded that palmitoyl carnitine, at concentrations which have previously been shown to occur in the cytoplasm during myocardial ischaemia, may interact directly with Ca2+ channels and may therefore be considered as an endogenous modulator of channel function.

TL;DR: A pharmacophore has been developed, based on the reported conformation—activity relationship of the 5-HT1A recognition site, defining a receptor map which accounts for different chemical classes.