J
John R. Fozard
Researcher at Novartis
Publications - 139
Citations - 11638
John R. Fozard is an academic researcher from Novartis. The author has contributed to research in topics: Agonist & Receptor. The author has an hindex of 43, co-authored 139 publications receiving 11538 citations. Previous affiliations of John R. Fozard include Marion Merrell Dow.
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Journal Article
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Daniel Hoyer,David E. Clarke,John R. Fozard,Paul R. Hartig,Graeme R. Martin,Ewan J. Mylecharane,Pramod R. Saxena,Patrick P.A. Humphrey +7 more
TL;DR: It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics, and it is important to rationalise in concert all of the available data from studies involving both operational approaches of the classical pharmacological type and those from molecular and cellular biology.
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Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
P.B. Bradley,G. Engel,Wasyl Feniuk,John R. Fozard,Patrick P.A. Humphrey,Derek N. Middlemiss,Ewan J. Mylecharane,B.P. Richardson,Pramod R. Saxena +8 more
TL;DR: This classification of 5-HT receptors into three main groups is based largely, but not exclusively, on data from studies in isolated peripheral tissues where definitive classification is possible, and is believed that this working classification will be relevant to functional responses to 5- HT in the central nervous system.
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8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.
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The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.
TL;DR: The residual behavioural effects of 8-OH-DPAT in reserpinised rats may, therefore, reflect the consequences of stimulation of the putative 5-HT1A receptor.
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MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors
TL;DR: MDL 72222 is the first reported selective and potent antagonist of responses mediated through the 5-HT receptors present on the terminal sympathetic neurones of the rabbit heart and on the neurones subserving the afferent limb of the Bezold-Jarisch reflex.