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Ann L. Beyer
Researcher at University of Virginia Health System
Publications - 66
Citations - 5363
Ann L. Beyer is an academic researcher from University of Virginia Health System. The author has contributed to research in topics: Transcription (biology) & Gene. The author has an hindex of 35, co-authored 66 publications receiving 4979 citations. Previous affiliations of Ann L. Beyer include University of Virginia.
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Journal ArticleDOI
A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis
François Dragon,Jennifer E. G. Gallagher,Patricia A. Compagnone-Post,Brianna M. Mitchell,Kara A. Porwancher,Karen A. Wehner,Steven Wormsley,Robert E. Settlage,Jeffrey Shabanowitz,Yvonne N. Osheim,Ann L. Beyer,Donald F. Hunt,Susan J. Baserga +12 more
TL;DR: A large ribonucleoprotein (RNP) complex from Saccharomyces cerevisiae that contains the U3 snoRNA and 28 proteins is purified and it is suggested that this complex may correspond to the terminal knobs present at the 5′ ends of nascent pre-rRNAs.
Journal ArticleDOI
Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.
Ann L. Beyer,Yvonne N. Osheim +1 more
TL;DR: Evidence is presented that pre-mRNA splicing occurs with a reasonable frequency on the nascent transcripts of early Drosophila embryo genes and that splice site selection may generally precede polyadenylation, which is consistent with the 'first-come-first-served' principle of splICE site selection.
Journal ArticleDOI
Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis
TL;DR: It is concluded that the loss of Top1 enhances inherent R-loop formation, particularly over the 5' region of the rDNA, imposing persistent transcription blocks when RNase H is limiting.
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In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes.
TL;DR: It is shown that overall initiation rate, and not the number of active genes, determines rRNA transcription rate during exponential growth in yeast.
Journal ArticleDOI
Pre-18S Ribosomal RNA Is Structurally Compacted into the SSU Processome Prior to Being Cleaved from Nascent Transcripts in Saccharomyces cerevisiae
Yvonne N. Osheim,Sarah L. French,Kristin M. Keck,Erica A. Champion,Krasimir Spasov,François Dragon,Susan J. Baserga,Ann L. Beyer +7 more
TL;DR: Depletion of individual components shows that cotranscriptional SSU processome formation is a sensitive indicator of the occurrence or timing of the early A0-A2 cleavages and depends on factors not isolated in preribosome complexes, as well as on favorable growth conditions.