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Anna Biernacka
Researcher at Medical University of Warsaw
Publications - 63
Citations - 2943
Anna Biernacka is an academic researcher from Medical University of Warsaw. The author has contributed to research in topics: Exome sequencing & Cyclin D. The author has an hindex of 21, co-authored 62 publications receiving 2269 citations. Previous affiliations of Anna Biernacka include University of Warsaw & Dartmouth–Hitchcock Medical Center.
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Journal ArticleDOI
TGF-β signaling in fibrosis
TL;DR: The role of TGF-β signaling pathways in the fibrotic response is summarized in this minireview, which summarizes the involvement of the canonical activin receptor-like kinase 5/Smad3 pathway in fibrosis.
Journal Article
Aging and Cardiac Fibrosis.
TL;DR: Understanding the pathogenesis of interstitial fibrosis in the aging heart and dissecting the mechanisms responsible for age-associated healing defects following cardiac injury are critical in order to design new strategies for prevention of adverse remodeling and heart failure in elderly patients.
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Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures
Thomas Clouaire,Vincent Rocher,Anahita Lashgari,Coline Arnould,Marion Aguirrebengoa,Anna Biernacka,Magdalena Skrzypczak,François Aymard,Bernard Fongang,Norbert Dojer,Norbert Dojer,Jason S. Iacovoni,Maga Rowicka,Krzysztof Ginalski,Jacques Côté,Gaëlle Legube +15 more
TL;DR: This study revealed the existence of a DSB-induced monoubiquitination-to-acetylation switch on histone H2B lysine 120, likely mediated by the SAGA complex, as well as higher-order signaling at HR-repaired DSBs whereby hist one H1 is evicted while ubiquitin and 53BP1 accumulate over the entire γH2AX domains.
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Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes
François Aymard,Marion Aguirrebengoa,Emmanuelle Guillou,Biola M. Javierre,Béatrix Bugler,Coline Arnould,Vincent Rocher,Jason S. Iacovoni,Anna Biernacka,Magdalena Skrzypczak,Krzysztof Ginalski,Maga Rowicka,Peter Fraser,Gaëlle Legube +13 more
TL;DR: Investigation of clustering of DNA double-strand breaks in mammalian cells reveals that, when damaged, active genes, compared with the rest of the genome, exhibit a distinctive behavior, remaining largely unrepaired and clustered in G1, and being repaired via homologous recombination in postreplicative cells.
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Endogenous Thrombospondin 1 Protects the Pressure-Overloaded Myocardium by Modulating Fibroblast Phenotype and Matrix Metabolism
Ying Xia,Marcin Dobaczewski,Carlos Gonzalez-Quesada,Wei Chen,Anna Biernacka,Na Li,Dong Wook Lee,Nikolaos G. Frangogiannis +7 more
TL;DR: TSP-1 upregulation in the pressure-overloaded heart critically regulates fibroblast phenotype and matrix remodeling by activating transforming growth factor-&bgr; signaling and by promoting matrix preservation, thus preventing chamber dilation.