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Coline Arnould
Researcher at University of Toulouse
Publications - 11
Citations - 634
Coline Arnould is an academic researcher from University of Toulouse. The author has contributed to research in topics: Chromatin & Homologous recombination. The author has an hindex of 6, co-authored 9 publications receiving 375 citations. Previous affiliations of Coline Arnould include Centre national de la recherche scientifique.
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Journal ArticleDOI
Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures
Thomas Clouaire,Vincent Rocher,Anahita Lashgari,Coline Arnould,Marion Aguirrebengoa,Anna Biernacka,Magdalena Skrzypczak,François Aymard,Bernard Fongang,Norbert Dojer,Norbert Dojer,Jason S. Iacovoni,Maga Rowicka,Krzysztof Ginalski,Jacques Côté,Gaëlle Legube +15 more
TL;DR: This study revealed the existence of a DSB-induced monoubiquitination-to-acetylation switch on histone H2B lysine 120, likely mediated by the SAGA complex, as well as higher-order signaling at HR-repaired DSBs whereby hist one H1 is evicted while ubiquitin and 53BP1 accumulate over the entire γH2AX domains.
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Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes
François Aymard,Marion Aguirrebengoa,Emmanuelle Guillou,Biola M. Javierre,Béatrix Bugler,Coline Arnould,Vincent Rocher,Jason S. Iacovoni,Anna Biernacka,Magdalena Skrzypczak,Krzysztof Ginalski,Maga Rowicka,Peter Fraser,Gaëlle Legube +13 more
TL;DR: Investigation of clustering of DNA double-strand breaks in mammalian cells reveals that, when damaged, active genes, compared with the rest of the genome, exhibit a distinctive behavior, remaining largely unrepaired and clustered in G1, and being repaired via homologous recombination in postreplicative cells.
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Loop extrusion as a mechanism for formation of DNA damage repair foci
Coline Arnould,Vincent Rocher,Anne-Laure Finoux,Thomas Clouaire,Kevin Li,Felix Zhou,Pierre Caron,Philippe E. Mangeot,Emiliano P. Ricci,Raphaël Mourad,James E. Haber,Daan Noordermeer,Gaëlle Legube +12 more
TL;DR: In this article, the authors show that topologically associating domains are functional units of the DNA damage response, and are instrumental for the correct establishment of γH2AX-53BP1 chromatin domains in a manner that involves one-sided cohesin-mediated loop extrusion on both sides of the DSB.
Journal ArticleDOI
A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair
Aline Marnef,Anne-Laure Finoux,Coline Arnould,Emmanuelle Guillou,Virginie Daburon,Vincent Rocher,Thomas Mangeat,Philippe E. Mangeot,Emiliano P. Ricci,Gaëlle Legube +9 more
TL;DR: The data indicate that rDNA break localization at the nucleolar periphery is not a direct consequence of transcriptional repression but rather is an active process that shares features with the mobilization of persistent DSB in active genes and heterochromatin.
Journal ArticleDOI
The Secret Life of Chromosome Loops upon DNA Double-Strand Break
Coline Arnould,Gaëlle Legube +1 more
TL;DR: The influence of initial and DSB-induced chromatin conformation and the strong potential of 3C-based technologies to decipher the contribution of chromosome architecture during DSB repair are discussed.