R
Robert Wagner
Researcher at University of Pittsburgh
Publications - 48
Citations - 1615
Robert Wagner is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Transplantation & Xenotransplantation. The author has an hindex of 19, co-authored 42 publications receiving 1405 citations.
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Journal ArticleDOI
Pig kidney graft survival in a baboon for 136 days: longest life‐supporting organ graft survival to date
Hayato Iwase,Hong Liu,Hong Liu,Martin Wijkstrom,Huidong Zhou,Huidong Zhou,Jagjit Singh,Hidetaka Hara,Mohamed Ezzelarab,Cassandra Long,Edwin Klein,Robert Wagner,Carol Phelps,David Ayares,Ron Shapiro,Abhinav Humar,David K. C. Cooper +16 more
TL;DR: The combination of a graft from a specific genetically engineered pig, an effective immunosuppressive regimen, and anti‐inflammatory agents prevented immune injury and a protein‐losing nephropathy, and delayed coagulation dysfunction encourages us that clinical renal xenotransplantation may become a reality.
Journal ArticleDOI
Selected physiologic compatibilities and incompatibilities between human and porcine organ systems.
Zuhaib Ibrahim,Zuhaib Ibrahim,Jamie Busch,Michel Awwad,Robert Wagner,Kevin D. Wells,David K. C. Cooper +6 more
TL;DR: The possibility of producing genetically altered pigs for organ transplantation is considered and the major potential physiologic incompatibilities relating to function of the kidney, heart, liver, lungs, pancreatic islets, and hormones are reviewed.
Journal ArticleDOI
Ranavirus infection of free-ranging and captive box turtles and tortoises in the united states
April J. Johnson,Allan P. Pessier,James F. X. Wellehan,April L. Childress,Terry M. Norton,Nancy L. Stedman,David C. Bloom,William Belzer,Valorie R. Titus,Valorie R. Titus,Robert Wagner,Jason W. Brooks,Jeffrey S. Spratt,Jeffrey S. Spratt,Elliott R. Jacobson +14 more
TL;DR: Five instances of Ranavirus infection in chelonians between 2003 and 2005 in Georgia, Florida, New York, and Pennsylvania, USA are described to suggest that certain amphibians and chelonian are infected with a similar virus and that different viruses exist among differentChelonians.
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THE INNATE IMMUNE RESPONSE AND ACTIVATION OF COAGULATION IN α1,3-GALACTOSYLTRANSFERASE GENE-KNOCKOUT XENOGRAFT RECIPIENTS
Mohamed Ezzelarab,Bertha Garcia,Agnes M. Azimzadeh,Hongtao Sun,Chih Che Lin,Hidetaka Hara,Sean Kelishadi,Tianshu Zhang,Yih Jyh Lin,Hao Chi Tai,Robert Wagner,J. Thacker,Noriko Murase,Kenneth R. McCurry,Rolf N. Barth,David Ayares,Richard N. Pierson,David K. C. Cooper +17 more
TL;DR: The data suggest that irrespective of the presence or absence of the adaptive immune response, early or late xenograft rejection is associated with activation of the innate immune system and porcine endothelial cell activation and primate TF expression by recipient innate immune cells may both contribute to the development of TM.
Journal ArticleDOI
Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance.
Burcin Ekser,Burcin Ekser,Cassandra Long,Gabriel J. Echeverri,Hidetaka Hara,Mohamed Ezzelarab,Chih Che Lin,M. E. de Vera,Robert Wagner,Edwin Klein,Roman F. Wolf,D. Ayares,David K. C. Cooper,Bruno Gridelli,Bruno Gridelli +14 more
TL;DR: It is anticipated that a pig liver could provide a period during which a patient in liver failure could be successfully bridged to allotransplantation.