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Robert Wagner

Researcher at University of Pittsburgh

Publications -  48
Citations -  1615

Robert Wagner is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Transplantation & Xenotransplantation. The author has an hindex of 19, co-authored 42 publications receiving 1405 citations.

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Pig kidney graft survival in a baboon for 136 days: longest life‐supporting organ graft survival to date

TL;DR: The combination of a graft from a specific genetically engineered pig, an effective immunosuppressive regimen, and anti‐inflammatory agents prevented immune injury and a protein‐losing nephropathy, and delayed coagulation dysfunction encourages us that clinical renal xenotransplantation may become a reality.
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Selected physiologic compatibilities and incompatibilities between human and porcine organ systems.

TL;DR: The possibility of producing genetically altered pigs for organ transplantation is considered and the major potential physiologic incompatibilities relating to function of the kidney, heart, liver, lungs, pancreatic islets, and hormones are reviewed.
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THE INNATE IMMUNE RESPONSE AND ACTIVATION OF COAGULATION IN α1,3-GALACTOSYLTRANSFERASE GENE-KNOCKOUT XENOGRAFT RECIPIENTS

TL;DR: The data suggest that irrespective of the presence or absence of the adaptive immune response, early or late xenograft rejection is associated with activation of the innate immune system and porcine endothelial cell activation and primate TF expression by recipient innate immune cells may both contribute to the development of TM.