Anna Cedzich

TL;DR: The localization of full-length polycystin-2 to intrACEllular membranes raises the possibility that the PKD2 gene product is a subunit of intracellular channel complexes.

TL;DR: The finding, that the PKD1 and PKD2 proteins interact with each other through their COOH termini, suggests that both proteins are part of the same protein complex or signal transduction pathway.

TL;DR: Polycystin-2 goes through the Golgi apparatus when going to the plasma membrane, but bypasses it en route to the ciliary membrane.

TL;DR: This work reports the first structure of a plant subtilase, SBT3 from tomato, in the active apo form and complexed with a chloromethylketone (cmk) inhibitor and presents the first structural evidence for an explicit function of PA domains in proteases revealing a vital role in the homo-dimerization ofSBT3 and in enzyme activation.

TL;DR: This work reports the first preliminary evidence that cyst formation is due not only to somatic mutations, but also the involvement of primary cilia, from two transgenic rats that contain a truncated human polycystin-2 cDNA.