T
Toshio Mochizuki
Researcher at Tokyo Medical and Dental University
Publications - 101
Citations - 3687
Toshio Mochizuki is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Autosomal dominant polycystic kidney disease & Kidney disease. The author has an hindex of 25, co-authored 94 publications receiving 3324 citations. Previous affiliations of Toshio Mochizuki include Albert Einstein College of Medicine & Yeshiva University.
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Journal ArticleDOI
PKD2, a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein
Toshio Mochizuki,Guanqing Wu,Tomohito Hayashi,Stavroulla Xenophontos,Barbera Veldhuisen,Jasper J. Saris,David Reynolds,Yiqiang Cai,Patricia A. Gabow,Alkis Pierides,William J. Kimberling,Martijn H. Breuning,Constantinos Deltas,Dorien J.M. Peters,Stefan Somlo +14 more
TL;DR: A second gene for autosomal dominant polycystic kidney disease was identified by positional cloning and it has amino acid similarity with PKD1, the Caenorhabditis elegans homolog of PKD 1, and the family of voltage-activated calcium channels.
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Identification and Characterization of Polycystin-2, the PKD2 Gene Product
Yiqiang Cai,Yoshiko Maeda,Anna Cedzich,Vicente E. Torres,Guanqing Wu,Tomohito Hayashi,Toshio Mochizuki,Jong Hoon Park,Ralph Witzgall,Stefan Somlo +9 more
TL;DR: The localization of full-length polycystin-2 to intrACEllular membranes raises the possibility that the PKD2 gene product is a subunit of intracellular channel complexes.
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Cloning of inv, a gene that controls left/right asymmetry and kidney development
Toshio Mochizuki,Yukio Saijoh,Ken Tsuchiya,Yasuaki Shirayoshi,Setsuo Takai,Choji Taya,Hiromichi Yonekawa,Kiyomi Yamada,Hiroshi Nihei,Norio Nakatsuji,Paul A. Overbeek,Hiroshi Hamada,Takahiko Yokoyama +12 more
TL;DR: Transgenic introduction of a minigene encoding the candidate protein restores normal left/right asymmetry and kidney development in the inv mutant, and indicates that the candidate gene is the only gene that is disrupted in inv mutants.
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Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation
Saori Nishio,Masahiko Hatano,Michio Nagata,Shigeo Horie,Takao Koike,Takeshi Tokuhisa,Toshio Mochizuki +6 more
TL;DR: Pkd1 plays a role in preventing immortalized proliferation of renal tubular epithelial cells through the induction of p53 and activation of JNK, which provides a novel understanding of the cystogenesis of ADPKD patients.
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A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2)
Barbera Veldhuisen,Jasper J. Saris,S. de Haij,Tomohito Hayashi,David Reynolds,Toshio Mochizuki,R. Elles,R. Fossdal,Nadja Bogdanova,M. A. van Dijk,Eliecer Coto,David Ravine,S. Nôrby,Christine Verellen-Dumoulin,Martijn H. Breuning,Stefan Somlo,Dorien J.M. Peters +16 more
TL;DR: It is suggested that the first step toward cyst formation in PKD2 patients is the loss of one functional copy of polycystin-2, which shows amino acid similarity to the PKD1 gene product and to the family of voltage-activated calcium channels.