Y
Yiqiang Cai
Researcher at Yale University
Publications - 35
Citations - 6216
Yiqiang Cai is an academic researcher from Yale University. The author has contributed to research in topics: Polycystin 2 & Polycystic kidney disease. The author has an hindex of 27, co-authored 31 publications receiving 5823 citations. Previous affiliations of Yiqiang Cai include Albert Einstein College of Medicine & Yeshiva University.
Papers
More filters
Journal ArticleDOI
PKD2, a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein
Toshio Mochizuki,Guanqing Wu,Tomohito Hayashi,Stavroulla Xenophontos,Barbera Veldhuisen,Jasper J. Saris,David Reynolds,Yiqiang Cai,Patricia A. Gabow,Alkis Pierides,William J. Kimberling,Martijn H. Breuning,Constantinos Deltas,Dorien J.M. Peters,Stefan Somlo +14 more
TL;DR: A second gene for autosomal dominant polycystic kidney disease was identified by positional cloning and it has amino acid similarity with PKD1, the Caenorhabditis elegans homolog of PKD 1, and the family of voltage-activated calcium channels.
Journal ArticleDOI
Polycystin-2 is an intracellular calcium release channel
Peter Koulen,Yiqiang Cai,Lin Geng,Yoshiko Maeda,Sayoko Nishimura,Ralph Witzgall,Barbara E. Ehrlich,Stefan Somlo +7 more
TL;DR: It is shown by single channel studies that polycystin-2 behaves as a calcium-activated, high conductance ER channel that is permeable to divalent cations and thatpolycystic kidney disease results from the loss of a regulated intracellular calcium release signalling mechanism.
Journal ArticleDOI
PKD1 interacts with PKD2 through a probable coiled-coil domain
TL;DR: A previously unrecognized coiled-coil domain within the C terminus of the PKD1 gene product, polycystin, is described and it is demonstrated that it binds specifically to the Cterminus of PKD2.
Journal ArticleDOI
Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease
Guanqing Wu,Vivette D. D'Agati,Yiqiang Cai,Glen S. Markowitz,Jong Hoon Park,David Reynolds,Yoshiko Maeda,Thanh C. Le,Harry Hou,Raju Kucherlapati,Winfried Edelmann,Stefan Somlo +11 more
TL;DR: Somatic loss of Pkd2 expression is both necessary and sufficient for renal cyst formation in ADPKD, suggesting that PKD2 occurs by a cellular recessive mechanism.
Journal ArticleDOI
Cardiac defects and renal failure in mice with targeted mutations in Pkd2.
Guanqing Wu,Glen S. Markowitz,Li Li,Vivette D. D'Agati,Stephen M. Factor,Lin Geng,S. Tibara,J. Tuchman,Yiqiang Cai,Yiqiang Cai,Jong Hoon Park,J. Van Adelsberg,Harry Hou,Raju Kucherlapati,Winfried Edelmann,Stefan Somlo,Stefan Somlo +16 more
TL;DR: The studies advance the understanding of the function of polycystin-2 in development and the mouse models recapitulate the complex human ADPKD phenotype, providing evidence that kidney and liver cyst formation associated with Pkd2 deficiency occurs by a two-hit mechanism.