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Anna Falk
Researcher at Karolinska Institutet
Publications - 79
Citations - 3409
Anna Falk is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 23, co-authored 69 publications receiving 2722 citations. Previous affiliations of Anna Falk include Karolinska University Hospital & Wellcome Trust Centre for Stem Cell Research.
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Journal ArticleDOI
Cross-talk between the Notch and TGF-{beta} signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
Andries Blokzijl,Camilla Dahlqvist,Eva Reissmann,Anna Falk,Annalena Moliner,Urban Lendahl,Carlos F. Ibáñez +6 more
TL;DR: Findings indicate that Notch and TGF-β signals are integrated by direct protein–protein interactions between the signal-transducing intracellular elements from both pathways.
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Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation
Camilla Dahlqvist,Andries Blokzijl,Gavin Chapman,Anna Falk,Karin Dannaeus,Carlos F. Ibâñez,Urban Lendahl +6 more
TL;DR: It is demonstrated that functional Notch signaling is required for BMP4-mediated block of differentiation of muscle stem cells, i.e. satellite cells and the myogenic cell line C2C12, and indicates that Notch has a crucial role in the execution of certain aspects of BMP-mediated differentiation control.
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Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons
Anna Falk,Philipp Koch,Jaideep Kesavan,Yasuhiro Takashima,Julia Ladewig,Michael Alexander,Ole Wiskow,Jignesh Tailor,Matthew Trotter,Steven M. Pollard,Austin Smith,Oliver Brüstle +11 more
TL;DR: It is proposed that lt-NES cells provide an interesting tool for studying human neurodevelopment and may serve as a standard system to facilitate comparative analyses of hESC and hiPSC-derived neural cells from control and diseased genetic backgrounds.
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Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture
Yirui Sun,Steven M. Pollard,Luciano Conti,Mauro Toselli,Gerardo Biella,Georgina Parkin,Lionel Willatt,Anna Falk,Elena Cattaneo,Austin Smith +9 more
TL;DR: This work describes the generation and long-term expansion of multiple human foetal neural stem (NS) cell lines in monolayer culture without genetic immortalization, and demonstrates that human NS cells are tripotent.
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Treatment of a Mouse Model of Spinal Cord Injury by Transplantation of Human Induced Pluripotent Stem Cell‐Derived Long‐Term Self‐Renewing Neuroepithelial‐Like Stem Cells
Yusuke Fujimoto,Masahiko Abematsu,Anna Falk,Keita Tsujimura,Tsukasa Sanosaka,Berry Juliandi,Berry Juliandi,Katsunori Semi,Masakazu Namihira,Setsuro Komiya,Austin Smith,Kinichi Nakashima +11 more
TL;DR: It is shown that transplanted hiPS‐lt‐NES cells differentiate into neural lineages in the mouse model of spinal cord injury (SCI) and promote functional recovery of hind limb motor function and it is revealed that transplants hiPS'lt‐ NES cell‐derived neurons, together with the surviving endogenous neurons, contributed to restored motor function.