M
Matthew Trotter
Researcher at Celgene
Publications - 73
Citations - 8721
Matthew Trotter is an academic researcher from Celgene. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 34, co-authored 72 publications receiving 7716 citations. Previous affiliations of Matthew Trotter include University of Cambridge & Wellcome Trust.
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Journal ArticleDOI
Derivation of pluripotent epiblast stem cells from mammalian embryos
I. Gabrielle M. Brons,Lucy E. Smithers,Matthew Trotter,Peter J. Rugg-Gunn,Bowen Sun,Susana M. Chuva de Sousa Lopes,Sarah K. Howlett,Amanda Clarkson,Lars Ährlund-Richter,Roger A. Pedersen,Ludovic Vallier +10 more
TL;DR: It is shown that pluripotent stem cells can be derived from the late epiblast layer of post-implantation mouse and rat embryos using chemically defined, activin-containing culture medium that is sufficient for long-term maintenance of human embryonic stem cells.
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Drug design by machine learning: support vector machines for pharmaceutical data analysis.
TL;DR: It is shown that the support vector machine (SVM) classification algorithm, a recent development from the machine learning community, proves its potential for structure-activity relationship analysis in a benchmark test, compared to several machine learning techniques currently used in the field.
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Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
Hsei-Wei Wang,Matthew Trotter,Dimitrios Lagos,Dimitra Bourboulia,Stephen Henderson,Taija Makinen,Stephen Elliman,Adrienne M. Flanagan,Kari Alitalo,Chris Boshoff +9 more
TL;DR: It is shown by gene expression microarrays that neoplastic cells of Kaposi sarcoma are closely related to lymphatic endothelial cells (LECs) and that Kaposi Sarcoma herpesvirus (KSHV) infects both LECs and blood vascular endothelial Cells (BECs) in vitro.
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Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
Ludovic Vallier,Sasha Mendjan,Stephanie Brown,Zhenzhi Chng,Adrian Kee Keong Teo,Lucy E. Smithers,Matthew Trotter,Matthew Trotter,Candy H.-H. Cho,Amelie Martinez,Peter J. Rugg-Gunn,Gabrielle Brons,Roger A. Pedersen +12 more
TL;DR: It is demonstrated that Activin/Nodal signalling controls expression of the key pluripotency factor Nanog in human ESCs and in mouse EpiSCs, which prevents neuroectoderm differentiation induced by FGF signalling and limits the transcriptional activity of the Smad2/3 cascade, blocking progression along the endoderm lineage.
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Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling
Vivian W. Y. Wong,Daniel E. Stange,Mahalia E. Page,Mahalia E. Page,Simon J.A. Buczacki,Agnieszka Wabik,Satoshi Itami,Marc van de Wetering,Richard Poulsom,Richard Poulsom,Nicholas A. Wright,Nicholas A. Wright,Matthew Trotter,Matthew Trotter,Fiona M. Watt,Fiona M. Watt,Doug J. Winton,Hans Clevers,Kim B. Jensen,Kim B. Jensen +19 more
TL;DR: It is shown that Lrig1, a negative-feedback regulator of the ErbB receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling.