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Anna Plaas
Researcher at Rush University Medical Center
Publications - 125
Citations - 7373
Anna Plaas is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Aggrecan & Cartilage. The author has an hindex of 47, co-authored 123 publications receiving 6967 citations. Previous affiliations of Anna Plaas include University of Iowa & University of South Florida.
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Biosynthetic response of cartilage explants to dynamic compression.
TL;DR: This study provides a framework for identifying both the physical and biological mechanisms by which dynamic compression can modulate chondrocyte biosynthesis and potentially allows in vitro evaluation of clinical strategies of continuous passive motion therapy to stimulate cartilage remodeling.
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Mechanical Regulation of Cartilage Biosynthetic Behavior: Physical Stimuli
TL;DR: Results suggest that the stimulation of chondrocyte biosynthesis by dynamic mechanical compression at amplitudes up to 10% (stresses up to 0.5 MPa) is related to changes in fluid flow and/or cell shape rather than changes in hydrostatic pressure.
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Binding of a Large Chondroitin Sulfate/Dermatan Sulfate Proteoglycan, Versican, to L-selectin, P-selectin, and CD44
TL;DR: It is shown that a large chondroitin sulfate proteoglycan, versican, derived from a renal adenocarcinoma cell line ACHN, binds L- selectin, P-selectin, and CD44 and that soluble CD44 directly binds to immobilized hyaluronic acid, CH, and all the CS chains examined.
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Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?
TL;DR: Evidence that certain extracellular matrix components of joint tissues (hyaluronan and fibronectin) may act as TLR stimuli are reviewed, and recent literature implicating TLR activation in osteoarthritis is summarized.
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Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy
TL;DR: Measured dimensions and polymer statistical analyses were used in conjunction with the results of Western analyses, chromatographic, and carbohydrate electrophoresis measurements to better understand the dependence of aggrecan structure and properties on its constituent GAG chains.