Anna Schubart

TL;DR: Animal model studies indicate an overall neuroprotective effect of FTY720 mediated at least in part by its actions within the CNS across the broad clinical spectrum of MS.

TL;DR: Results show that siponimod has neuroprotective effects in the CNS of EAE mice, which are likely independent of its peripheral immune effect, suggesting that this drug could be effective in limiting neurodegenerative pathological processes in MS.

TL;DR: This study suggests that BAF312 can modulate glial cell function and attenuate demyelination in organotypic slice cultures, without altering the levels of cytokines, such as IL6.

TL;DR: The discovery of a highly potent, reversible, and selective small-molecule inhibitor of factor B, a serine protease that drives the central amplification loop of the AP, and its use for systemic treatment of complement-mediated diseases is described.

TL;DR: The identification of potent and selective small-molecule inhibitors of FD that efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes are described.