Eleonora Piras

TL;DR: It is proposed that inability to control EBV infection during inactive MS could set the stage for intracerebral viral reactivation and disease relapse.

TL;DR: Results show that siponimod has neuroprotective effects in the CNS of EAE mice, which are likely independent of its peripheral immune effect, suggesting that this drug could be effective in limiting neurodegenerative pathological processes in MS.

TL;DR: The relatively high proportion of IP changes in RR-MS patients seems to confirmed the work hypothesis and warrants more work to confirm the result on a larger sample, and to understand the implications for related immunological disturbances and intestinal microbiota alterations.

TL;DR: Clinically achievable concentrations of olaparib were able to induce cell death in the majority of primary AML case samples and tested cell lines and phosphorylation of the histone H2AFX (γH2AX) was associated with drug sensitivity.

TL;DR: The findings encourage the design of pilot studies to explore the potential clinical benefit of ASC alone or in combination with ATO in advanced AML and APL and the mechanism of cell killing appeared to be related to increased oxidative stress and overproduction of ROS in a non-quantitative fashion.