Paul Erbel

TL;DR: In this article, the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2b-NS 3pro complex with a substrate-based inhibitor were reported.

TL;DR: The identification of potent and selective small-molecule inhibitors of FD that efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes are described.

TL;DR: A molecular corrector rescues an enzyme deficiency by substituting for the mutated residue, inspiring new potential precision therapies to increase mutant enzyme activity in other deficiencies.

TL;DR: Two hit finding approaches leading to the discovery of new chemical matter for this pivotal protease of the complement system are described: in silico active site mapping for hot spot identification to guide rational structure-based design and NMR screening of focused and diverse fragment libraries.

TL;DR: A concise two-pronged hit discovery approach enabled the first high-resolution X-ray cocrystal structures of adenain with inhibitors bound and revealed the binding mode of 1 and 2.