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Anna V. Naumova
Researcher at University of Washington
Publications - 23
Citations - 3164
Anna V. Naumova is an academic researcher from University of Washington. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 9, co-authored 18 publications receiving 2874 citations. Previous affiliations of Anna V. Naumova include Tomsk State University.
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Journal ArticleDOI
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
Michael A. Laflamme,Kent Chen,Anna V. Naumova,Veronica Muskheli,James A. Fugate,Sarah K. Dupras,Hans Reinecke,Chunhui Xu,Mohammad Hassanipour,Chris O'Sullivan,Lila R. Collins,Yinhong Chen,Elina Minami,Edward A. Gill,Shuichi Ueno,Chun Yuan,Joseph K. Gold,Charles E. Murry +17 more
TL;DR: This work generated highly purified human cardiomyocytes using a readily scalable system for directed differentiation that relies on activin A and BMP4, and identified a cocktail of pro-survival factors that limitsCardiomyocyte death after transplantation.
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Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates
Yen Wen Liu,Billy Chen,Xiulan Yang,James A. Fugate,Faith A. Kalucki,Akiko Futakuchi-Tsuchida,Larry A. Couture,Keith W. Vogel,Clifford A. Astley,Audrey Baldessari,Jason Ogle,Creighton W. Don,Zachary L. Steinberg,Stephen P. Seslar,Stephanie A. Tuck,Hiroshi Tsuchida,Anna V. Naumova,Sarah K. Dupras,Milly S. Lyu,James Chun-I Lee,Dale W. Hailey,Hans Reinecke,Lil Pabon,Benjamin H. Fryer,W. Robb MacLellan,R. Scott Thies,Charles E. Murry +26 more
TL;DR: It is shown that transplantation of ∼750 million cryopreserved human embryonic stem cell–derived cardiomyocytes (hESC-CMs) enhances cardiac function in macaque monkeys with large myocardial infarctions and provides durable improvement in left ventricular function.
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Clinical imaging in regenerative medicine
TL;DR: Imaging studies in brain, heart and islets share a common set of challenges, including developing novel labeling approaches to improve detection thresholds and early delineation of toxicity and function, and addressing safety concerns associated with genetic labels.
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Human embryonic stem cell-derived cardiomyocytes engraft but do not alter cardiac remodeling after chronic infarction in rats.
Sarah Fernandes,Anna V. Naumova,Wei-Zhong Zhu,Michael A. Laflamme,Joseph D. Gold,Charles E. Murry +5 more
TL;DR: Echocardiography and MRI analyses showed no significant difference in left ventricular structure or function between these 4 groups at any time point of the study, suggesting that human cardiomyocytes do not affect cardiac remodeling in a rat model of chronic myocardial infarction.
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Ferritin overexpression for noninvasive magnetic resonance imaging-based tracking of stem cells transplanted into the heart.
TL;DR: The feasibility of ferritin overexpression in mouse skeletal myoblasts and the successful detection of transgenic cells by MRI in vitro and in vivo after transplantation into the infarcted mouse heart lay the groundwork for using the MRI gene reporter ferritIn to track stem cells transplanted to the heart.