Chris O'Sullivan

TL;DR: This work generated highly purified human cardiomyocytes using a readily scalable system for directed differentiation that relies on activin A and BMP4, and identified a cocktail of pro-survival factors that limitsCardiomyocyte death after transplantation.

TL;DR: Cells in media containing Flt‐3L, thrombopoietin, and SCF, individually or in combination, showed almost complete differentiation after 6 weeks in culture, demonstrating that hESCs can be maintained in nonconditioned medium using growth factors.

TL;DR: These results demonstrate that cardiomyocytes of high quality can be efficiently generated and cryopreserved using hESCs maintained in serum-free medium, a step forward towards the application of these cells to human clinical use or drug discovery.

TL;DR: These studies demonstrate that an oncolytic virus driven by the telomerase promoter can be used to effectively kill a wide variety of cancer cell types and has the potential to treat primary and metastatic cancer of diverse origins.

TL;DR: It is shown that culturing hES cell-derived cardiomyocytes in serum-free medium as described here should facilitate the use of the cells for in vitro and in vivo applications.