J
Joseph D. Gold
Researcher at Stanford University
Publications - 85
Citations - 9215
Joseph D. Gold is an academic researcher from Stanford University. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 34, co-authored 85 publications receiving 8364 citations. Previous affiliations of Joseph D. Gold include Cardiovascular Institute of the South & Beckman Research Institute.
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Journal ArticleDOI
Feeder-free growth of undifferentiated human embryonic stem cells.
Chunhui Xu,Margaret S. Inokuma,Jerrod Denham,Kathaleen Golds,Pratima Kundu,Joseph D. Gold,Melissa K. Carpenter +6 more
TL;DR: A successful feeder-free hES culture system in which undifferentiated cells can be maintained for at least 130 population doublings and are suitable for scaleup production is demonstrated.
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Chemically defined generation of human cardiomyocytes
Paul W. Burridge,Elena Matsa,Praveen K. Shukla,Ziliang C Lin,Jared M. Churko,Antje D. Ebert,Feng Lan,Sebastian Diecke,Bruno C. Huber,Nicholas M. Mordwinkin,Jordan R. Plews,Oscar J. Abilez,Bianxiao Cui,Joseph D. Gold,Joseph C. Wu +14 more
TL;DR: This work systematically developed an optimized cardiac differentiation strategy, using a chemically defined medium consisting of just three components: the basal medium RPMI 1640, L-ascorbic acid 2-phosphate and rice-derived recombinant human albumin, which was effective in 11 hiPSC lines tested.
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Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts
Yuji Shiba,Sarah Fernandes,Wei-Zhong Zhu,Dominic Filice,Veronica Muskheli,Jonathan Kim,Nathan J. Palpant,Jay Gantz,Kara White Moyes,Hans Reinecke,Benjamin Van Biber,Todd F. Dardas,John L. Mignone,Atshushi Izawa,Ramy Hanna,Mohan N. Viswanathan,Joseph D. Gold,Michael I. Kotlikoff,Narine Sarvazyan,Matthew W. Kay,Charles E. Murry,Michael A. Laflamme +21 more
TL;DR: Injured hearts with hESC-CM grafts show improved mechanical function and a significantly reduced incidence of both spontaneous and induced ventricular tachycardia, providing support for the continued development of h ESC-based cardiac therapies for both mechanical and electrical repair.
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Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.
TL;DR: In this article, state-of-the-art methods for generating de novo cardiomyocytes from human pluripotent stem cells (hPSCs) and reprogrammed fibroblasts are discussed.
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Basic Fibroblast Growth Factor Supports Undifferentiated Human Embryonic Stem Cell Growth Without Conditioned Medium
Chunhui Xu,Elen S. Rosler,Jianjie Jiang,Jane S. Lebkowski,Joseph D. Gold,Chris O'Sullivan,Karen Delavan-Boorsma,Michael Mok,Adrienne Bronstein,Melissa K. Carpenter +9 more
TL;DR: Cells in media containing Flt‐3L, thrombopoietin, and SCF, individually or in combination, showed almost complete differentiation after 6 weeks in culture, demonstrating that hESCs can be maintained in nonconditioned medium using growth factors.