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Anne-Renee Hartman
Researcher at Myriad Genetics
Publications - 66
Citations - 3339
Anne-Renee Hartman is an academic researcher from Myriad Genetics. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 20, co-authored 63 publications receiving 2452 citations. Previous affiliations of Anne-Renee Hartman include Pharmaceutical Product Development & Stanford University.
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Journal ArticleDOI
Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.
Melinda L. Telli,Kirsten Timms,Julia Reid,Bryan T. Hennessy,Gordon B. Mills,Kristin C. Jensen,Zoltan Szallasi,William T. Barry,Eric P. Winer,Nadine Tung,Steven J. Isakoff,Paula D. Ryan,April Greene-Colozzi,Alexander Gutin,Zaina Sangale,Diana Iliev,Chris Neff,Victor Abkevich,Joshua Jones,Jerry S. Lanchbury,Anne-Renee Hartman,Judy Garber,James M. Ford,Daniel P. Silver,Andrea L. Richardson +24 more
TL;DR: HR deficiency identifies TNBC tumors, including BRCA1/2 nonmutated tumors more likely to respond to platinum-containing therapy, and response was higher in patients with high HRD scores.
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Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next‐generation sequencing with a 25‐gene panel
Nadine Tung,Chiara Battelli,Brian Allen,Rajesh R. Kaldate,Satish Bhatnagar,Karla R. Bowles,Kirsten Timms,Judy Garber,Christina I. Herold,Leif W. Ellisen,Jill Krejdovsky,Kim DeLeonardis,Kristin Sedgwick,Kathleen A. Soltis,Benjamin B. Roa,Richard J. Wenstrup,Anne-Renee Hartman +16 more
TL;DR: The authors assessed the frequency of deleterious germline mutations among individuals with breast cancer who were referred for BRCA1 and BRCa2 gene testing using a panel of 25 genes associated with inherited cancer predisposition.
Journal ArticleDOI
Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer
Nadine Tung,Nan Lin,John Kidd,Brian Allen,Nanda Singh,Richard J. Wenstrup,Anne-Renee Hartman,Eric P. Winer,Judy Garber +8 more
TL;DR: Factors that predict for BRCA1/2 mutations do not predict for mutations in other breast/ovarian cancer susceptibility genes when these genes are analyzed as a single group.
Journal ArticleDOI
Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.
Matthew B. Yurgelun,Matthew H. Kulke,Charles S. Fuchs,Brian Allen,Hajime Uno,Jason L. Hornick,Chinedu Ukaegbu,Lauren K. Brais,Philip G. McNamara,Robert J. Mayer,Deborah Schrag,Jeffrey A. Meyerhardt,Kimmie Ng,John Kidd,Nanda Singh,Anne-Renee Hartman,Richard J. Wenstrup,Sapna Syngal +17 more
TL;DR: Neither proband age at CRC diagnosis, family history of CRC, nor personal history of other cancers significantly predicted the presence of pathogenic mutations in non-LS genes, but MSI/MMR testing reliably identifies LS probands, although 7.0% of patients with CRC carry non- LS mutations.
Journal ArticleDOI
BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.
Anne-Renee Hartman,James M. Ford +1 more
TL;DR: It is shown that BRCA1 specifically enhances the GGR pathway, independent of p53, and can induce p53-independent expression of the NER genes XPC, DDB2, and GADD45, suggesting a multistep model of carcinogenesis.