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Steven J. Isakoff
Researcher at Harvard University
Publications - 223
Citations - 17340
Steven J. Isakoff is an academic researcher from Harvard University. The author has contributed to research in topics: Breast cancer & Metastatic breast cancer. The author has an hindex of 46, co-authored 179 publications receiving 13361 citations. Previous affiliations of Steven J. Isakoff include National Comprehensive Cancer Network & New York University.
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Journal ArticleDOI
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Min Yu,Aditya Bardia,Ben S. Wittner,Shannon L. Stott,Malgorzata E. Smas,David T. Ting,Steven J. Isakoff,Jordan C. Ciciliano,Marissa N. Wells,Ajay Shah,Kyle Concannon,Maria C. Donaldson,Lecia V. Sequist,Elena F. Brachtel,Dennis C. Sgroi,José Baselga,Sridhar Ramaswamy,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more
TL;DR: A role for EMT in the blood-borne dissemination of human breast cancer is supported as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)–β pathway components and the FOXC1 transcription factor.
Journal ArticleDOI
Breast Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology
William J. Gradishar,Benjamin O. Anderson,Jame Abraham,Rebecca Aft,Doreen M. Agnese,Kimberly H. Allison,Sarah L. Blair,Harold J. Burstein,Chau T. Dang,Anthony D. Elias,Sharon H. Giordano,Matthew P. Goetz,Lori J. Goldstein,Steven J. Isakoff,Jairam Krishnamurthy,Janice A. Lyons,P. Kelly Marcom,Jennifer M. Matro,Ingrid A. Mayer,Meena S. Moran,Joanne E. Mortimer,Ruth O'Regan,Sameer A. Patel,Lori J. Pierce,Hope S. Rugo,Amy M. Sitapati,Karen L. Smith,Mary Lou Smith,Hatem Soliman,Erica Stringer-Reasor,Melinda L. Telli,John H. Ward,Jessica Young,Jennifer L. Burns,Rashmi Kumar +34 more
TL;DR: The NCCN Guidelines specific to the workup and treatment of patients with recurrent/stage IV breast cancer are discussed in this article.
Journal ArticleDOI
A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
Xiao Jun Ma,Zuncai Wang,Paula D. Ryan,Steven J. Isakoff,Anne Barmettler,Andrew P. Fuller,Beth Muir,Gayatry Mohapatra,Ranelle C. Salunga,J. Todd Tuggle,Yen Tran,Diem Tran,Ana Tassin,Paul Amon,Wilson Wang,Wei Wang,Edward Enright,Kimberly Stecker,Eden Estepa-Sabal,Barbara L. Smith,Jerry Younger,Ulysses J. Balis,James S. Michaelson,Atul K. Bhan,Karleen Habin,Thomas M. Baer,Joan S. Brugge,Daniel A. Haber,Mark G. Erlander,Dennis C. Sgroi +29 more
TL;DR: An expression signature predictive of disease-free survival was reduced to a two-gene ratio, HOXB13 versus IL17BR, which outperformed existing biomarkers and may be useful for identifying patients appropriate for alternative therapeutic regimens in early-stage breast cancer.
Journal ArticleDOI
The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression
Kishore K. Wary,Fabrizio Mainiero,Steven J. Isakoff,Eugene E. Marcantonio,Filippo G. Giancotti +4 more
TL;DR: It is shown that the association of specific integrins with Shc regulates cell survival and cell cycle progression and that Shc is necessary and sufficient for activation of the MAP kinase pathway in response to integrin ligation.
Journal ArticleDOI
Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.
Melinda L. Telli,Kirsten Timms,Julia Reid,Bryan T. Hennessy,Gordon B. Mills,Kristin C. Jensen,Zoltan Szallasi,William T. Barry,Eric P. Winer,Nadine Tung,Steven J. Isakoff,Paula D. Ryan,April Greene-Colozzi,Alexander Gutin,Zaina Sangale,Diana Iliev,Chris Neff,Victor Abkevich,Joshua Jones,Jerry S. Lanchbury,Anne-Renee Hartman,Judy Garber,James M. Ford,Daniel P. Silver,Andrea L. Richardson +24 more
TL;DR: HR deficiency identifies TNBC tumors, including BRCA1/2 nonmutated tumors more likely to respond to platinum-containing therapy, and response was higher in patients with high HRD scores.