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Anne Van Hecken
Researcher at Katholieke Universiteit Leuven
Publications - 35
Citations - 1843
Anne Van Hecken is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Pharmacokinetics & Calcitonin gene-related peptide. The author has an hindex of 18, co-authored 34 publications receiving 1714 citations.
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Journal ArticleDOI
Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers.
Anne Van Hecken,Jules I. Schwartz,Marleen Depré,Inge De Lepeleire,Aimee Dallob,Wesley Tanaka,Kathleen Wynants,Agnes Buntinx,Jef Arnout,Peggy H. Wong,David L. Ebel,Barry J. Gertz,Paul J. De Schepper +12 more
TL;DR: Rofecoxib had no significant effect on urinary excretion of 11‐dehydro TXB2, a COX‐ 1‐derived product, and these data support the contention that rofecoxIB is the only drug of the regimens tested that uniquely inhibits COx‐2 without affectingCOX‐1.
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Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model.
Elliot W. Ehrich,Aimee Dallob,Inge De Lepeleire,Anne Van Hecken,Denis Riendeau,Wei-ying Yuan,Arturo G. Porras,Johanna Wittreich,James R. Seibold,Paul J. De Schepper,Donald R. Mehlisch,Barry J. Gertz +11 more
TL;DR: Nonsteroidal anti‐inflammatory drugs such as aspirin, ibuprofen, and indomethacin (INN, indometacin) inhibit both the constitutive and inducible isoforms of cyclooxygenase, leading to the hypothesis that COX‐2 inhibition primarily accounts for the therapeutic properties of NSAIDs.
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[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
H. Donald Burns,Koen Van Laere,Sandra M. Sanabria-Bohórquez,Terence G. Hamill,Guy Bormans,Wai-Si Eng,Ray E Gibson,Christine E. Ryan,Brett Connolly,Shil Patel,Stephen Krause,Amy Vanko,Anne Van Hecken,Patrick Dupont,Inge De Lepeleire,Paul Rothenberg,S. Aubrey Stoch,Josee Cote,William K. Hagmann,James P. Jewell,Linus S. Lin,Ping Liu,Mark T. Goulet,Keith Gottesdiener,John A. Wagner,Jan de Hoon,Luc Mortelmans,Tung M. Fong,Richard Hargreaves +28 more
TL;DR: Autoradiographic studies in rhesus monkey brain showed that [18F]MK-9470 binding is aligned with the reported distribution of CB1 receptors with high specific binding in the cerebral cortex, cerebellum, caudate/putamen, globus pallidus, substantia nigra, and hippocampus, and PET imaging studies in human research subject demonstrated behavior very similar to that seen in monkeys.
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Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion
K. Six,Tinne Daems,Jan de Hoon,Anne Van Hecken,Marleen Depré,Marie-Paule Bouche,Paul Prinsen,Geert Verreck,Jef Peeters,Marcus E. Brewster,Guy Van den Mooter +10 more
TL;DR: The present results indicate that hot-stage extrusion can be considered as a valuable alternative for manufacturing solid dispersions of itraconazole.
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In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4232
Eric D. Hostetler,Aniket D. Joshi,Sandra Sanabria-Bohorquez,Hong Fan,Zhizhen Zeng,Mona Purcell,Liza Gantert,Kerry Riffel,Mangay Williams,Stacey O'Malley,Patricia Miller,Harold G. Selnick,Steven N. Gallicchio,Ian M. Bell,Christopher A. Salvatore,Stefanie A. Kane,Chi-Chung Li,Richard Hargreaves,Tjibbe de Groot,Guy Bormans,Anne Van Hecken,Inge Derdelinckx,Jan de Hoon,Tom Reynders,Ruben Declercq,Inge De Lepeleire,William P. Kennedy,Rebecca L. Blanchard,Eugene E. Marcantonio,Cyrille Sur,Jacquelynn J. Cook,Koen Van Laere,Jeffrey L. Evelhoch +32 more
TL;DR: Application of [11C]MK-4232 in human PET studies revealed that telcagepant achieved only low receptor occupancy at an efficacious dose (140 mg PO), therefore, it is unlikely that antagonism of central CGRP-R is required for migraine efficacy.