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Anne W. Young
Researcher at New York University
Publications - 12
Citations - 504
Anne W. Young is an academic researcher from New York University. The author has contributed to research in topics: Antimicrobial peptides & Antimicrobial. The author has an hindex of 7, co-authored 12 publications receiving 454 citations. Previous affiliations of Anne W. Young include L'Oréal.
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Journal ArticleDOI
Length Effects in Antimicrobial Peptides of the (RW)n Series
Zhigang Liu,Anna Brady,Anne W. Young,Brian Rasimick,Kang Chen,Chunhui Zhou,Neville R. Kallenbach +6 more
TL;DR: Circular dichroism spectroscopy indicates that these short peptides appear to be unfolded in aqueous solution but acquire structure in the presence of phospholipids, and the (RW)3 represents the optimal chain length in terms of the efficacy of synthesis and selectivity as evaluated by the hemolytic index.
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Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents
Chunhui Zhou,Jaeki Min,Zhigang Liu,Anne W. Young,Heather Deshazer,Tian Gao,Young-Tae Chang,Neville R. Kallenbach +7 more
TL;DR: A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity and designed and screened several combinatorial libraries based on 1,3,5-triazine as a template.
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Antimicrobial dendrimer active against Escherichia coli biofilms
Shuyu Hou,Chunhui Zhou,Zhigang Liu,Anne W. Young,Zhengshuang Shi,Dacheng Ren,Neville R. Kallenbach +6 more
TL;DR: Investigating the ability of a previously reported antimicrobial peptide dendrimer (RW)(4D) to inactivate Escherichia coli RP437 in planktonic culture and in biofilms reveals that most bacteria in a preformed biofilm lose viability after treatment with this peptide.
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Tuning the membrane selectivity of antimicrobial peptides by using multivalent design.
Zhigang Liu,Anne W. Young,Po Hu,Amanda J. Rice,Chunhui Zhou,Yingkai Zhang,Neville R. Kallenbach +6 more
TL;DR: The hypothesis is that multi/polyvalent RW peptide display can enhance the effectiveness of antibacterials against MDR bacterial strains and is originally based on the two-state model of AMP action proposed by Huang, which is broadly consistent with other current ideas.
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Effects of Trp- and Arg-containing antimicrobial-peptide structure on inhibition of Escherichia coli planktonic growth and biofilm formation
TL;DR: The results suggest that hexameric and octameric peptides are potent inhibitors of both bacterial planktonic growth and biofilm formation, while the octamering peptide can also disperse existing biofilms and kill the detached cells.