Anne W. Young

TL;DR: Circular dichroism spectroscopy indicates that these short peptides appear to be unfolded in aqueous solution but acquire structure in the presence of phospholipids, and the (RW)3 represents the optimal chain length in terms of the efficacy of synthesis and selectivity as evaluated by the hemolytic index.

TL;DR: A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity and designed and screened several combinatorial libraries based on 1,3,5-triazine as a template.

TL;DR: Investigating the ability of a previously reported antimicrobial peptide dendrimer (RW)(4D) to inactivate Escherichia coli RP437 in planktonic culture and in biofilms reveals that most bacteria in a preformed biofilm lose viability after treatment with this peptide.

TL;DR: The hypothesis is that multi/polyvalent RW peptide display can enhance the effectiveness of antibacterials against MDR bacterial strains and is originally based on the two-state model of AMP action proposed by Huang, which is broadly consistent with other current ideas.

TL;DR: The results suggest that hexameric and octameric peptides are potent inhibitors of both bacterial planktonic growth and biofilm formation, while the octamering peptide can also disperse existing biofilms and kill the detached cells.