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Anneliese Schimpl
Researcher at University of Würzburg
Publications - 88
Citations - 6638
Anneliese Schimpl is an academic researcher from University of Würzburg. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 35, co-authored 88 publications receiving 6514 citations. Previous affiliations of Anneliese Schimpl include University of Göttingen.
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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene.
TL;DR: The data provide evidence for a primary role of the immune system in the etiology of ulcerative colitis and strongly suggest that the disease results from an abnormal immune response to a normal antigenic stimulus.
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Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting.
TL;DR: It is found that mice homozygous for the IL-2 gene mutation are normal with regard to thymocyte and peripheral T-cell subset composition, but that a dysregulation of the immune system is manifested by reduced polyclonal in vitro T- cell responses and by dramatic changes in the isotype levels of serum immunoglobulins.
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Replacement of t-cell function by a t-cell product.
TL;DR: The existence of two distinct factors, one of which can completely replace T-cells, is reported, which is believed to be based on the heavy antigenic stimulation provided by the histocompatibility antigens carried by the B-cells.
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Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice.
TL;DR: The data suggest that activation of T cells in the absence of IL‐2 fails to generate a signal which is necessary to activate the apoptotic pathway and thus leads to an accumulation of antigen‐experienced cells and the chronic inflammatory responses observed in IL‐ 2‐deficient mice.
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The Human Immunodeficiency Virus Type 1 (HIV-1) Vpu Protein Interferes with an Early Step in the Biosynthesis of Major Histocompatibility Complex (MHC) Class I Molecules
Thomas Kerkau,Igor Bacik,Jack R. Bennink,Jonathan W. Yewdell,Thomas Hünig,Anneliese Schimpl,Ulrich S. Schubert +6 more
TL;DR: It is proposed that Vpu-induced downregulation of class I molecules may be an important factor in the evolutionary selection of the HIV-1–specific vpu gene by contributing to the inability of CD8+ T cells to eradicate HIV- 1 from infected individuals.