A
Annemarie M.A. de Graaf
Researcher at Radboud University Nijmegen
Publications - 8
Citations - 342
Annemarie M.A. de Graaf is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Internal medicine & Glycomimetic. The author has an hindex of 4, co-authored 6 publications receiving 264 citations. Previous affiliations of Annemarie M.A. de Graaf include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Targeting Aberrant Sialylation in Cancer Cells Using a Fluorinated Sialic Acid Analog Impairs Adhesion, Migration, and In Vivo Tumor Growth
Christian Büll,Thomas J. Boltje,Melissa Wassink,Annemarie M.A. de Graaf,Floris L. van Delft,Martijn H. den Brok,Gosse J. Adema +6 more
TL;DR: The results indicate that P-3Fax-Neu5Ac is a powerful glycomimetic capable of inhibiting aberrant sialylation that can potentially be used for anticancer therapy.
Journal ArticleDOI
Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread
Christian Büll,Thomas J. Boltje,Eric A. W. van Dinther,Timo Peters,Annemarie M.A. de Graaf,Jeanette H. W. Leusen,Martin Kreutz,Carl G. Figdor,Martijn H. den Brok,Gosse J. Adema +9 more
TL;DR: These findings stress the importance of sialoglycans in cancer metastasis and advocate that sialic acid blockade using rationally designed glycomimetics targeted to cancer cells can effectively prevent cancer metastases.
Journal ArticleDOI
Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation.
Martijn H. den Brok,Christian Büll,Melissa Wassink,Annemarie M.A. de Graaf,Jori A. L. Wagenaars,Marthe Minderman,Mayank Thakur,Sebastian Amigorena,Eric Onno Rijke,Schrier Carla Christina,Gosse J. Adema +10 more
TL;DR: It is demonstrated that SBAs uniquely induce intracellular lipid bodies (LBs) in the CD11b+ DC subset in vitro and in vivo, and this link adjuvant activity to LB formation will aid the application of SBAs as a cancer vaccine component, and will stimulate development of new adjuvants enhancing T-cell-mediated immunity.
Journal ArticleDOI
DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells
Marleen Ansems,Jonas Nørskov Søndergaard,Anieta M. Sieuwerts,Maaike W. G. Looman,Marcel Smid,Annemarie M.A. de Graaf,Vanja de Weerd,Malou Zuidscherwoude,John A. Foekens,John W.M. Martens,Gosse J. Adema +10 more
TL;DR: Data show that DC-SCRIPT acts as a novel regulator of CDKN2B and induces cell cycle arrest in ESR1-positive breast cancer cells.
Journal ArticleDOI
Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes
Tonke K. Raaijmakers,Renske J.E. van den Bijgaart,Martijn H. den Brok,Melissa Wassink,Annemarie M.A. de Graaf,Jori A. L. Wagenaars,Stefan Nierkens,Stefan Nierkens,Marleen Ansems,Gert Jan Scheffer,Gosse J. Adema +10 more
TL;DR: It is shown that simultaneous administration of cytidyl guanosyl (CpG) with saponin-based adjuvants following cryoablation affects multifunctional T-cell numbers and interleukin (IL)-1 induced polymorphonuclear neutrophil recruitment in the tumor draining lymph nodes, relative to either adjuvant alone.