A
Annette Schell-Steven
Researcher at Hoffmann-La Roche
Publications - 2
Citations - 397
Annette Schell-Steven is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Renal function & Neuroblastoma RAS viral oncogene homolog. The author has an hindex of 2, co-authored 2 publications receiving 359 citations.
Papers
More filters
Journal ArticleDOI
Pharmacodynamic Effects and Mechanisms of Resistance to Vemurafenib in Patients With Metastatic Melanoma
Kerstin Trunzer,Anna C. Pavlick,Lynn M. Schuchter,Rene Gonzalez,Grant A. McArthur,Thomas E. Hutson,Stergios J. Moschos,Keith T. Flaherty,Kevin B. Kim,Jeffrey S. Weber,Peter Hersey,Georgina V. Long,Donald P. Lawrence,Patrick A. Ott,Ravi K. Amaravadi,Karl D. Lewis,Igor Puzanov,Roger S. Lo,Astrid Koehler,Mark M. Kockx,Olivia Spleiss,Annette Schell-Steven,Houston Gilbert,Louise Cockey,Gideon Bollag,Richard J. Lee,Andrew K. Joe,Jeffrey A. Sosman,Antoni Ribas +28 more
TL;DR: Vemurafenib inhibits tumor proliferation and oncogenic BRAF signaling through the MAPK pathway and inhibition downstream of BRAF should help to overcome acquired resistance.
Journal ArticleDOI
Cardiovascular risk markers associated with arterial calcification in patients with chronic kidney disease Stages 3 and 4.
Chek Ing Kiu Weber,Guillemette Duchateau-Nguyen,Corinne Solier,Annette Schell-Steven,Ricardo Hermosilla,Everson Nogoceke,Geoffrey A. Block +6 more
TL;DR: Elevated plasma levels of several inflammatory biomarkers are significantly associated with arterial calcification in CKD Stages 3 and 4 patients, and may help the development of CV risk-assessment algorithms for better management of these patients.