E
Everson Nogoceke
Researcher at Hoffmann-La Roche
Publications - 24
Citations - 1397
Everson Nogoceke is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Macular degeneration & Type 2 diabetes. The author has an hindex of 12, co-authored 24 publications receiving 910 citations. Previous affiliations of Everson Nogoceke include Polish Academy of Sciences & University of Dundee.
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Journal ArticleDOI
Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future
Johanna M. Colijn,Gabriëlle H.S. Buitendijk,Elena Prokofyeva,Dalila Alves,Maria Luz Cachulo,Anthony P. Khawaja,Anthony P. Khawaja,Audrey Cougnard-Gregoire,Bénédicte M. J. Merle,Christina Korb,Maja G. Erke,Alain M. Bron,Eleftherios Anastasopoulos,Magda A. Meester-Smoor,Tatiana Segato,Stefano Piermarocchi,Paulus T. V. M. de Jong,Paulus T. V. M. de Jong,Johannes R. Vingerling,Fotis Topouzis,Catherine Creuzot-Garcher,Geir Bertelsen,Norbert Pfeiffer,Astrid E. Fletcher,Paul J. Foster,Rufino Silva,Jean-François Korobelnik,Cécile Delcourt,Caroline C.W. Klaver,Caroline C.W. Klaver,Soufiane Ajana,Blanca Arango-Gonzalez,Verena Arndt,Vaibhav Bhatia,Shomi S. Bhattacharya,Marc Biarnés,Anna Borrell,Sebastian Bühren,Sofia Calado,Sascha Dammeier,Eiko K. de Jong,Berta de la Cerda,Anneke I. den Hollander,Francisco J. Diaz-Corrales,Sigrid Diether,Eszter Emri,Tanja Endermann,Lucia L. Ferraro,Míriam Garcia,Thomas J. Heesterbeek,Sabina Honisch,Carel B. Hoyng,Eveline Kersten,Ellen Kilger,Hanno Langen,Imre Lengyel,Phil Luthert,Cyrille Maugeais,Magda A. Meester-Smoor,Jordi Monés,Everson Nogoceke,Tunde Peto,Frances M. Pool,Eduardo Rodríguez,Marius Ueffing,Karl U. Ulrich Bartz-Schmidt,Elisabeth M. van Leeuwen,Timo Verzijden,Markus Zumbansen,Niyazi Acar,Eleftherios Anastosopoulos,Augusto Azuara-Blanco,Arthur A.B. Bergen,Christine Binquet,Alan C. Bird,Lionel Bretillon,Gabrielle Buitendijk,Maria Luz Cachulo,Usha Chakravarthy,Michelle P.Y. Chan,Petrus Chang,Johanna Colijn,Philippa Cumberland,José Cunha-Vaz,Vincent Daien,Gabor Deak,Marie-Noëlle Delyfer,Anneke den Hollander,Martha Dietzel,Maja Gran Erke,Sascha Fauser,Robert Finger,Astrid Fletcher,Paul Foster,Panayiota Founti,Arno P. Göbel,Theo G. M. F. Gorgels,Jakob Grauslund,Franz H. Grus,Christopher J Hammond,Catherine Helmer,Hans-Werner Hense,Manuel M. Hermann,René Hoehn,Ruth E Hogg,Frank G. Holz,Carel B. Hoyng,Nomdo M. Jansonius,Sarah F. Janssen,Anthony P Khawaja,Caroline C W Klaver,Julia Lamparter,Mélanie Le Goff,Sérgio Leal,Yara T. E. Lechanteur,Terho Lehtimäki,Andrew J. Lotery,Irene Leung,Matthias M. Mauschitz,Benedicte Merle,Verena Meyer zu Westrup,Edoardo Midena,Stefania Miotto,Alireza Mirshahi,Sadek Mohan-Saïd,Michael Mueller,Alyson Muldrew,Sandrina Nunes,Konrad Oexle,Jugnoo S Rahi,Olli T. Raitakari,Luisa Ribeiro,Marie-Bénédicte Rougier,José Sahel,Aggeliki Salonikiou,Clarisa I. Sánchez,Steffen Schmitz-Valckenberg,Cedric Schweitzer,Jasmin Shehata,Giuliana Silvestri,Christian Simader,Eric H Souied,Henriët Springelkamp,Robyn J. Tapp,Virginie J. M. Verhoeven,Therese von Hanno,Stela Vujosevic,Katie M Williams,Christian Wolfram,Jennifer L.Y. Yip,Jennyfer Zerbib,Isabella Zwiener +151 more
TL;DR: A decreasing prevalence of AMD and an improvement in visual acuity in CNV occuring over the past 2 decades in Europe is observed and healthier lifestyles and implementation of anti–vascular endothelial growth factor treatment are the most likely explanations.
Journal ArticleDOI
Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases
Jörg T. Regula,Peter Lundh von Leithner,Richard Foxton,Veluchamy A Barathi,Chui Ming Gemmy Cheung,Sai Bo Bo Tun,Yeo Sia Wey,Daiju Iwata,Miroslav Dostálek,Jörg Moelleken,Kay Stubenrauch,Everson Nogoceke,Gabriella Widmer,Pamela Strassburger,Michael Janusz Koss,Michael Janusz Koss,Christian Klein,David T. Shima,Guido Hartmann +18 more
TL;DR: RG7716 showed greater efficacy than anti‐VEGF‐A alone in a non‐human primate laser‐induced CNV model after intravitreal delivery, and modification of RG7716's FcRn and FcγR binding sites disabled the antibodies' Fc‐mediated effector functions, making it a potential next‐generation therapy for neovascular indications of the eye.
Journal ArticleDOI
Simultaneous Inhibition of Angiopoietin-2 and Vascular Endothelial Growth Factor-A with Faricimab in Diabetic Macular Edema: BOULEVARD Phase 2 Randomized Trial
Jayashree Sahni,Sunil S. Patel,Pravin U. Dugel,Arshad M. Khanani,Chirag Jhaveri,Charles C. Wykoff,Vrinda S. Hershberger,Meike Pauly-Evers,Shamil Sadikhov,Piotr Szczesny,Dietmar Schwab,Everson Nogoceke,Aaron Osborne,Robert James Weikert,Sascha Fauser +14 more
TL;DR: The BOULEVARD trial met its primary end point; faricimab demonstrated statistically superior visual acuity gains versus ranibizumab at week 24 in treatment-naïve patients, and the benefit of simultaneous inhibition of angiopoietin-2 and VEGF-A with faricIMab for patients with DME is suggested.
Journal ArticleDOI
A new perspective on lipid research in age-related macular degeneration
Elisabeth M. van Leeuwen,Eszter Emri,Benedicte Merle,Johanna M. Colijn,Eveline Kersten,Audrey Cougnard-Gregoire,Sascha Dammeier,Magda A. Meester-Smoor,Frances M. Pool,Eiko K. de Jong,Cécile Delcourt,Eduardo Rodrigez-Bocanegra,Marc Biarnés,Philip J. Luthert,Marius Ueffing,Caroline C W Klaver,Everson Nogoceke,Anneke I. den Hollander,Imre Lengyel +18 more
TL;DR: This article critically evaluates what has been reported in the literature and identifies new directions needed to bring about a significant advance in the understanding of the role for lipids in AMD to develop potential new treatment strategies through targeting the lipid homeostasis.
Journal ArticleDOI
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
Michele Solimena,Michele Solimena,Anke M. Schulte,Lorella Marselli,Florian Ehehalt,Daniela Richter,Manuela Kleeberg,Hassan Mziaut,Klaus-Peter Knoch,Julia Parnis,Marco Bugliani,Afshan Siddiq,Afshan Siddiq,Anne Jörns,Frédéric Burdet,Robin Liechti,Mara Suleiman,Daniel Margerie,Farooq Syed,Marius Distler,Robert Grützmann,Enrico Petretto,Enrico Petretto,Aida Moreno-Moral,Aida Moreno-Moral,C. Wegbrod,Anke Sönmez,Katja Pfriem,A. Friedrich,Jörn Meinel,Claes B. Wollheim,Gustavo B. Baretton,Raphael Scharfmann,Everson Nogoceke,Ezio Bonifacio,Dorothée Sturm,Birgit Meyer-Puttlitz,Ugo Boggi,Hans-Detlev Saeger,Franco Filipponi,Mathias Lesche,Paolo Meda,Andreas Dahl,Leonore Wigger,Ioannis Xenarios,Mario Falchi,Bernard Thorens,Jürgen Weitz,Krister Bokvist,Sigurd Lenzen,Guy A. Rutter,Philippe Froguel,Manon von Bulow,Mark Ibberson,Piero Marchetti +54 more
TL;DR: These studies enabled the stringent definition of a novel transcriptomic signature of type 2 diabetic islets, regardless of islet source and isolation procedure, which indicates differences possibly due to peculiarities of these hyperglycaemic conditions.