https://cyberleninka.org/article/n/195435.pdf

Hibiscus sabdariffa L. - A phytochemical and pharmacological review

Plant secondary metabolites have been a fertile area of chemical investigation for many years, driving the development of both analytical chemistry and of new synthetic reactions and methodologies. The subject is multi-disciplinary with chemists, biochemists and plant scientists all contributing to our current understanding. In recent years there has been an upsurge in interest from other disciplines, related to the realisation that secondary metabolites are dietary components that may have a considerable impact on human health, and to the development of gene technology that permits modulation of the contents of desirable and undesirable components. Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet addresses this wider interest by covering the main groups of natural products from a chemical and biosynthetic perspective with illustrations of how genetic engineering can be applied to manipulate levels of secondary metabolites of economic value as well as those of potential importance in diet and health. These descriptive chapters are augmented by chapters showing where these products are found in the diet, how they are metabolised and reviewing the evidence for their beneficial bioactivity. © 2006 by Blackwell Publishing Ltd.

Plant Secondary Metabolites: Occurrence, Structure And Role In The Human Diet

Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats.

Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression.

Hibiscus sabdariffa Linn. is an annual herbaceous shrub, cultivated for its flowers although leaves and seeds have also been used in traditional medicine. The calyces of the plant are used as a refrigerant in the form of tea, to make jellies and jams. The plant is reported to contain proteins, fats, carbohydrates, flavonoids, acids, minerals and vitamins. The plant has been reported to have antihypertensive, hepatoprotective, antihyperlipidemic, anticancer and antioxidant properties. The present paper is an overview on its phytochemical and pharmacological properties reported in the literature.

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Hibiscus sabdariffa Linn.-An overview

The present study quantitatively investigated the antioxidant effects of the aqueous extracts from dried calyx of Hibiscus sabdariffa LINN. (roselle) in vitro using rat low-density lipoprotein (LDL). Formations of the conjugated dienes and thiobarbituric acid reactive substances (TBARs) were monitored as markers of the early and later stages of the oxidation of LDL, respectively. Thus, we demonstrated that the dried calyx extracts of roselle exhibits strong antioxidant activity in Cu(2+)-mediated oxidation of LDL (p<0.05) in vitro. The inhibitory effect of the extracts on LDL oxidation was dose-dependent at concentrations ranging from 0.1 to 5 mg/ml. Moreover, 5 mg/ml of roselle inhibited TBARs-formation with greater potency than 100 microM of vitamin E. In conclusion, this study provides a quantitative insight into the potent antioxidant effect of roselle in vitro.

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Anocha Utaipat

Papers

Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats.

Antioxidant Effects of Aqueous Extracts from Dried Calyx of Hibiscus sabdariffa LINN. (Roselle) in Vitro Using Rat Low-Density Lipoprotein (LDL)