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Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats.

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TLDR
The lines of evidence suggest that the aqueous extracts from the dried calyx of roselle possess both antioxidant effects against LDL oxidation and hypolipidemic effects in vivo, however, its mechanism(s) of action remains to be elucidated.
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This article is published in Journal of Ethnopharmacology.The article was published on 2006-01-16. It has received 249 citations till now. The article focuses on the topics: Hibiscus sabdariffa & TBARS.

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Hibiscus sabdariffa L. - A phytochemical and pharmacological review

TL;DR: In vitro and in vivo studies as well as some clinical trials provide some evidence mostly for phytochemically poorly characterised Hs extracts which showed antibacterial, anti-oxidant, nephro- and hepato-protective, renal/diuretic effect, effects on lipid metabolism (anti-cholesterol), anti-diabetic and anti-hypertensive effects among others.
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Plant Secondary Metabolites: Occurrence, Structure And Role In The Human Diet

TL;DR: The authors suggest that the use of probiotics and prebiotics to modulate the gut flora composition in old age and the impact of dietary modulation of the gut microflora through dietary means should be considered.

Hibiscus sabdariffa Linn.-An overview

TL;DR: Hibiscus sabdariffa linn is an annual herbaceous shrub, cultivated for its flowers although leaves and seeds have also been used in traditional medicine as discussed by the authors.
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Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases.

TL;DR: A comprehensive view of the state-of-the-art literature on anthocyanins is provided, summarizing recent findings on their chemistry, biosynthesis, nutritional value and on their effects on human health.
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Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: A comprehensive review of animal and human studies

TL;DR: This comprehensive body of evidence suggests that extracts of HS are promising as a treatment of hypertension and hyperlipidemia, however more high quality animal and human studies informed by actual therapeutic practices are needed to provide recommendations for use that have the potential for widespread public health benefit.
References
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Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

TL;DR: A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.
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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
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Enzymatic determination of total serum cholesterol.

TL;DR: An enzymatic method is described for determination of total serum cholesterol by use of a single aqueous reagent and has excellent precision.
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The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum

TL;DR: The relatively low density of the lipoproteins was utilized by Lindgren, Elliott, and Gofman to separate them from the other serum proteins by ultracentrifugal flotation, and quantitation was subsequently performed by refractometric methods in the analytical ultracentRifuge.
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A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples

TL;DR: The original Lowry method of protein determination has been modified by the addition of sodium dodecyl sulfate in the alkali reagent and an increase in the amount of copper tartrate reagent to be used with membrane and lipoprotein preparations without prior solubilization or lipid extraction.
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