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Ansi Chang
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 27
Citations - 8110
Ansi Chang is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Multiple sclerosis & Oligodendrocyte. The author has an hindex of 25, co-authored 27 publications receiving 7558 citations. Previous affiliations of Ansi Chang include Cleveland Clinic.
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Journal ArticleDOI
Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions.
TL;DR: The hypothesis that demyelination, axonal transection, dendritic tran section, and apoptotic loss of neurons in the cerebral cortex contribute to neurological dysfunction in MS patients is supported.
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Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
TL;DR: Understanding the cellular interactions between premyelinating oligodendrocytes, axons, and the microenvironment of lesions of multiple sclerosis may lead to effective strategies for enhancing remyelination.
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Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
Ranjan Dutta,Jennifer McDonough,Xinghua Yin,John W. Peterson,Ansi Chang,Thalia Torres,Tatyana I. Gudz,Wendy B. Macklin,David A. Lewis,Robert J. Fox,Richard A. Rudick,Karoly Mirnics,Bruce D. Trapp +12 more
TL;DR: Development of neuroprotective therapies will require elucidation of the molecular mechanisms by which neurons and axons degenerate, according to the role of demyelinated axons in multiple sclerosis.
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NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions.
Ansi Chang,Akiko Nishiyama,John W. Peterson,John W. Peterson,John W. Prineas,Bruce D. Trapp,Bruce D. Trapp +6 more
TL;DR: These studies identify cells with phenotypic markers of endogenous oligodendrocyte progenitors in the mature human CNS and suggest that functional subpopulations of NG2-positive cells exist in MS lesions, suggesting a viable target for future therapies intended to enhance remyelination in MS patients.
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Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
Stephen A. Back,Thérèse M. F. Tuohy,Hanqin Chen,Nicholas Wallingford,Andrew Craig,Jaime Struve,Ning Ling Luo,Fatima Banine,Ying Liu,Ansi Chang,Bruce D. Trapp,Bruce F. Bebo,Mahendra S. Rao,Larry S. Sherman +13 more
TL;DR: It is found that the glycosaminoglycan hyaluronan accumulates in demyelinated lesions from individuals with multiple sclerosis and in mice with experimental autoimmune encephalomyelitis.