R
Ranjan Dutta
Researcher at Cleveland Clinic
Publications - 72
Citations - 6408
Ranjan Dutta is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Multiple sclerosis & Remyelination. The author has an hindex of 27, co-authored 67 publications receiving 5261 citations. Previous affiliations of Ranjan Dutta include Case Western Reserve University & Cleveland Clinic Lerner College of Medicine.
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Journal ArticleDOI
Control of microglial neurotoxicity by the fractalkine receptor
Astrid E. Cardona,Erik P. Pioro,Margaret E. Sasse,Volodymyr Kostenko,Sandra M. Cardona,Ineke M. Dijkstra,De Ren Huang,Grahame J. Kidd,Stephen M. Dombrowski,Ranjan Dutta,Jar Chi Lee,Donald N. Cook,Steffen Jung,Sergio A. Lira,Dan R. Littman,Richard M. Ransohoff +15 more
TL;DR: Augmenting CX3CR1 signaling may protect against microglial neurotoxicity, whereas CNS penetration by pharmaceutical CX2CR1 antagonists could increase neuronal vulnerability.
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Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
Ranjan Dutta,Jennifer McDonough,Xinghua Yin,John W. Peterson,Ansi Chang,Thalia Torres,Tatyana I. Gudz,Wendy B. Macklin,David A. Lewis,Robert J. Fox,Richard A. Rudick,Karoly Mirnics,Bruce D. Trapp +12 more
TL;DR: Development of neuroprotective therapies will require elucidation of the molecular mechanisms by which neurons and axons degenerate, according to the role of demyelinated axons in multiple sclerosis.
Journal ArticleDOI
Pathogenesis of axonal and neuronal damage in multiple sclerosis
Ranjan Dutta,Bruce D. Trapp +1 more
TL;DR: Therapeutic interventions directed toward several mechanisms lead to axon loss need to be tested for their efficacy in enhancing axon survival and, ultimately, their ability to delay progression of neurologic disability in patients with MS.
Journal ArticleDOI
Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis.
Ranjan Dutta,Bruce D. Trapp +1 more
TL;DR: The etiology, mechanisms and progress made in determining the cause of axonal and neuronal loss in MS are discussed, with a focus on the sixth decade of the disease.
Journal ArticleDOI
Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4
Zhihong Chen,Walid Jalabi,Karl B. Shpargel,Kenneth T. Farabaugh,Ranjan Dutta,Xinghua Yin,Grahame J. Kidd,Cornelia C. Bergmann,Stephen A. Stohlman,Bruce D. Trapp +9 more
TL;DR: It is shown here that neuronal cell death and lesion volumes are significantly reduced in LPS-treated animals following experimental brain injury, suggesting that activated microglia participate in neuroprotection and that this neuroprotection is likely achieved through reduction of inhibitory axosomatic synapses.