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Anthony M. Jevnikar
Researcher at University of Western Ontario
Publications - 166
Citations - 8432
Anthony M. Jevnikar is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Transplantation & Antigen. The author has an hindex of 49, co-authored 163 publications receiving 7849 citations. Previous affiliations of Anthony M. Jevnikar include London Health Sciences Centre & University of Groningen.
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Journal ArticleDOI
Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule.
Jonathan A. Hill,Scott Southwood,Alessandro Sette,Anthony M. Jevnikar,David A. Bell,Ewa Cairns +5 more
TL;DR: It is demonstrated that the conversion of arginine to citrulline at the peptide side-chain position interacting with the shared epitope significantly increases peptide-MHC affinity and leads to the activation CD4+ T cells in DR4-IE tg mice.
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Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.
Gang Chen,Hua Qian,Thomas E. Starzl,Hongtao Sun,Bertha Garcia,Ximo Wang,Yishai Wise,Yuanqing Liu,Ying Xiang,Laura Copeman,Weihua Liu,Anthony M. Jevnikar,Anthony M. Jevnikar,Anthony M. Jevnikar,William Wall,William Wall,David K. C. Cooper,Noriko Murase,Yifan Dai,Wan-yu Wang,Yu-liang Xiong,David J.G. White,Robert Zhong +22 more
TL;DR: It is suggested that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans.
Journal ArticleDOI
Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice
Jonathan A. Hill,David A. Bell,David A. Bell,William Brintnell,David Yue,Bret Wehrli,Anthony M. Jevnikar,Anthony M. Jevnikar,David M. Lee,Wolfgang Hueber,Wolfgang Hueber,William H. Robinson,William H. Robinson,Ewa Cairns +13 more
TL;DR: It is demonstrated that posttranslationally modified citrullinated fibrinogen leads to a selective increase in antigenic peptide affinity for major histocompatibility complex (MHC) class II molecules that carry the RA-associated shared epitope, such as HLA-DRB1*0401 (DR4).
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Inhibitory Feedback Loop Between Tolerogenic Dendritic Cells and Regulatory T Cells in Transplant Tolerance
Wei-Ping Min,Dejun Zhou,Thomas E. Ichim,Gill H. Strejan,Xiaoping Xia,Jinming Yang,Xuyan Huang,Bertha Garcia,David White,David White,Patrick Dutartre,Anthony M. Jevnikar,Robert Zhong +12 more
TL;DR: Treg and Tol-DC generated in vitro were functional based on their suppressive activity in vitro, consistent with the notion that tolerance induction is associated with a self-maintaining regulatory loop in which Tol- DC induce the generation of Treg from naive T cells and Treg programs the generation from DC progenitors.
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MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells.
Rudolf P. Wuthrich,Laurie H. Glimcher,Mary A. Yui,Anthony M. Jevnikar,Stephanie E. Dumas,Vicki E. Kelley +5 more
TL;DR: These cell lines have characteristics most consistent with a proximal tubular origin and bear characteristics of accessory cells such as processing and presentation of antigen and TNF-alpha gene expression, suggesting that PT have the capacity to participate in the pathogenesis of immune renal injury.