Antje Arnold

TL;DR: This review summarizes common and less frequent adverse events that have been discovered in preclinical and clinical investigations assessing cell therapies for stroke, and describes potential complications of clinically applicable administration procedures, detrimental interactions between therapeutic cells, and the pathophysiological environment that they are placed into.

TL;DR: The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling and there are contentious data regarding the extent to which telomeres are elongated, telomerase activity is reconstituted, and mitochondria are reorganized in iPSCs.

TL;DR: It is concluded that uracil nucleotides exert specific P2 receptor‐mediated effects on midbrain‐derived human NPCs, and may be used to enhance both proliferation and dopaminergic differentiation.

TL;DR: It is concluded that human GRPs can extend the survival of transplanted shiverer mice prior to production of mature myelin, while mouse GRPs fail to extend animal survival despite the early presence of matureMyelin.

TL;DR: Using this method, it was demonstrated swift activation of pluripotency associated genes in human fibroblasts and use of the polymeric transfections reagent polyethylenimine proved superior to other transfection methods.