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Alexander Storch
Researcher at University of Rostock
Publications - 281
Citations - 10282
Alexander Storch is an academic researcher from University of Rostock. The author has contributed to research in topics: Neural stem cell & Parkinson's disease. The author has an hindex of 49, co-authored 260 publications receiving 8991 citations. Previous affiliations of Alexander Storch include Dresden University of Technology & University of Ulm.
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Journal ArticleDOI
Direct reprogramming of fibroblasts into neural stem cells by defined factors.
Dong Wook Han,Dong Wook Han,Natalia Tapia,Andreas Hermann,Kathrin Hemmer,Susanne Höing,Marcos J. Araúzo-Bravo,Holm Zaehres,Guangming Wu,Stefan Frank,Sören Moritz,Boris Greber,Ji Hun Yang,Hoon Taek Lee,Jens Christian Schwamborn,Alexander Storch,Hans R. Schöler,Hans R. Schöler +17 more
TL;DR: It is shown that a combination of transcription factors induces mouse fibroblasts to directly acquire a neural stem cell identity-which is term as induced neural stem cells (iNSCs).
Journal ArticleDOI
GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak
Yvonne G. Weber,Alexander Storch,Thomas V. Wuttke,Knut Brockmann,Judith S. Kempfle,Snezana Maljevic,Lucia Margari,Christoph Kamm,Susanne A. Schneider,Stephan M. Huber,Arnulf Pekrun,Robert Roebling,Guiscard Seebohm,Saisudha Koka,Camelia Lang,Eduard Kraft,Dragica Blazevic,Alberto Salvo-Vargas,Michael Fauler,Felix M. Mottaghy,Alexander Münchau,Mark J. Edwards,Anna Presicci,Francesco Margari,Thomas Gasser,Florian Lang,Kailash P. Bhatia,Frank Lehmann-Horn,Holger Lerche +28 more
TL;DR: It is proposed that the dyskinesias result from an exertion-induced energy deficit that may cause episodic dysfunction of the basal ganglia, and that the hemolysis with echinocytosis may result from alterations in intracellular electrolytes caused by a cation leak through mutant GLUT1.
Journal ArticleDOI
A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases.
Uwe Freudenberg,Andreas Hermann,Petra B. Welzel,Katja Stirl,Sigrid C. Schwarz,Milauscha Grimmer,Andrea Zieris,Woranan Panyanuwat,Stefan Zschoche,Dorit Meinhold,Alexander Storch,Carsten Werner +11 more
TL;DR: A modular system of biohybrid hydrogels based on covalently cross-linked Heparin and star-shaped poly(ethylene glycols) (star-PEG) in which network characteristics can be gradually varied while heparin contents remain constant is presented.
Journal ArticleDOI
Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications.
Alexander Storch,Christine Schneider,Martin Wolz,Yannic Stürwald,Angelika Nebe,Per Odin,Andreas Mahler,G. Fuchs,Wolfgang H. Jost,K. Ray Chaudhuri,Rainer Koch,Heinz Reichmann,Georg Ebersbach +12 more
TL;DR: Patterns of NMS fluctuations are heterogeneous and complex, but psychic NMS fluctuate more frequently and severely, but demographic parameters and motor function do not correlate with NMS or nonmotor fluctuation severities in fluctuating PD.
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Transcriptional Profiles of CD133+ and CD133− Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin
Claudio Lottaz,Dagmar Beier,Katharina Meyer,Praveen Kumar,Andreas Hermann,Johannes Schwarz,Markus Junker,Peter J. Oefner,Ulrich Bogdahn,Jörg Wischhusen,Rainer Spang,Alexander Storch,Christoph P. Beier,Christoph P. Beier +13 more
TL;DR: Comparing CSC lines with their putative cells of origin, the data suggest that the heterogeneous tumor entity GBM may derive from cells that have preserved or acquired properties of either fNSC or aNSC but lost the corresponding differentiation potential.