Antoine Geinoz

TL;DR: It is shown that the subcutaneous administration of transforming growth factor- beta 1 to rats results in the formation of a granulation tissue in which alpha-SM actin expressing myofibroblasts are particularly abundant, suggesting that TGF beta 1 plays an important role in my ofibroblast differentiation during wound healing and fibrocontractive diseases by regulating the expression of alpha- SM actin in these cells.

TL;DR: It is reported here that ED-A FN deposition precedes α-SM actin expression by fibroblasts during granulation tissue evolution in vivo and after TGFβ1 stimulation in vitro, and a hitherto unknown mechanism of cytokine-determined gene stimulation based on the generation of an ECM-derived permissive outside in signaling is identified.

TL;DR: The results show that 2 distinct SMC subpopulations can be recovered from the pig coronary artery media, and the study of these sub Populations will be useful for understanding the mechanisms of restenosis.

TL;DR: The results indicate that S100A4 is a marker of porcine R-SMCs in vitro and of intimal SMCs during intimal thickening development, and is also a markers of a large population of human atheromatous and restenotic SMCs.

TL;DR: The results suggest that the expression of CRBP-1 is a marker of arterial SMC activation after endothelial injury in vivo and that CR BP-1 and probably retinoids participate in this process.