Antoine-Guy Lopez

TL;DR: Intraadrenal regulatory mechanisms observed in aldosterone-producing adenomas (APA), although globally similar to those occurring in the normal adrenal gland, harbor alterations at different levels, which tend to strengthen the potency of paracrine signals to activate ald testosterone secretion.

TL;DR: The data suggest that the intra-adrenal serotonergic regulatory system represents a potential target for development of both adrenal imaging methods to evaluate the lateralization of aldosterone production, and pharmacological treatments of primary aldosteronism.

TL;DR: Aldosterone breakthrough is described as an elevation of plasma aldosterone levels (PALs) during chronic administration of angiotensin-converting enzyme inhibitors to reduce the chance of meningitis and other potentially life-threatening complications.

TL;DR: Pregnancy may favor surges in plasma catecholamine and hypertensive crises through hCG-induced stimulation of epinephrine production by pheochromocytomas through the influence of estradiol and the pregnancy hormone hCG.

TL;DR: The paracrine factors involved in these intraadrenal regulatory mechanisms may thus represent valuable targets for future pharmacological treatments of adrenal diseases as discussed by the authors, which is the most common cause of the adrenal disorders associated with corticosteroid excess.