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Antoine Hamel
Researcher at University of Nantes
Publications - 72
Citations - 1090
Antoine Hamel is an academic researcher from University of Nantes. The author has contributed to research in topics: Vancomycin & Medicine. The author has an hindex of 18, co-authored 66 publications receiving 924 citations. Previous affiliations of Antoine Hamel include Centre Hospitalier Universitaire de Nantes.
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In Vivo Efficacy of Ceftaroline (PPI-0903), a New Broad-Spectrum Cephalosporin, Compared with Linezolid and Vancomycin against Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus in a Rabbit Endocarditis Model
Cédric Jacqueline,Jocelyne Caillon,Virginie Le Mabecque,Anne-Françoise Miègeville,Antoine Hamel,Denis Bugnon,James Yigong Ge,Gilles Potel +7 more
TL;DR: Using the rabbit endocarditis model, ceftaroline exhibited superior bactericidal in vivo activity against resistant S. aureus strains and appeared to be the most effective drug against a heterogeneous glycopeptide-intermediate S.aureus strain.
Journal ArticleDOI
Mutations in FAM111B Cause Hereditary Fibrosing Poikiloderma with Tendon Contracture, Myopathy, and Pulmonary Fibrosis
Sandra Mercier,Sébastien Küry,Gasnat Shaboodien,Darren T. Houniet,Nonhlanhla P. Khumalo,Chantal Bou-Hanna,Nathalie Bodak,Valérie Cormier-Daire,Albert David,Laurence Faivre,Dominique Figarella-Branger,Romain K. Gherardi,Elise Glen,Antoine Hamel,Christian L. Laboisse,Cédric Le Caignec,Pierre Lindenbaum,Armelle Magot,Arnold Munnich,Jean-Marie Mussini,Komala Pillay,Thahira Rahman,Richard Redon,Emmanuelle Salort-Campana,Mauro Santibanez-Koref,Christel Thauvin,Sébastien Barbarot,Bernard Keavney,Bernard Keavney,Stéphane Bézieau,Bongani M. Mayosi +30 more
TL;DR: Evidence is provided of the involvement of FAM111B in congenital poikiloderma and multisystem fibrosis by whole-exome sequencing and single-nucleotide mutations code for amino acid changes that are clustered within a putative trypsin-like cysteine/serine peptidase domain of FAM 111B.
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In Vivo Efficacy of Continuous Infusion versus Intermittent Dosing of Linezolid Compared to Vancomycin in a Methicillin-Resistant Staphylococcus aureus Rabbit Endocarditis Model
Cédric Jacqueline,Eric Batard,Lucia Perez,David Boutoille,Antoine Hamel,Jocelyne Caillon,M. F. Kergueris,Gilles Potel,Denis Bugnon +8 more
TL;DR: Continuous infusion of linezolid could be an appropriate alternative to the use of glycopeptides for the treatment of severe methicillin-resistant S. aureus infections.
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Familial acampomelic form of campomelic dysplasia caused by a 960 kb deletion upstream of SOX9.
Claire Lecointre,Olivier Pichon,Antoine Hamel,Yves Heloury,Laurence Michel-Calemard,Yves Morel,Albert David,Cédric Le Caignec +7 more
TL;DR: It is shown that the size of the deletion was 960 kb in the XY‐DSD child and her mother, both affected, and the deletion lying from 517 kb to 1.477 Mb upstream of SOX9 remove severalhighly conserved elements and reduce the minimum critical size and therefore the number of highly conserved sequence elements responsible for ACD.
Journal ArticleDOI
Efficacy of the new cephalosporin ceftaroline in the treatment of experimental methicillin-resistant Staphylococcus aureus acute osteomyelitis
Cédric Jacqueline,Gilles Amador,Jocelyne Caillon,Virginie Le Mabecque,Eric Batard,Anne-Françoise Miègeville,Donald Biek,Yigong Ge,Gilles Potel,Antoine Hamel +9 more
TL;DR: Ceftaroline is supported as a promising therapeutic option for the treatment of severe MRSA infections, including osteomyelitis after being the only drug to exhibit significant activity against MRSA in infected joint fluid.