Anton P. McCaffrey

TL;DR: This paper showed that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates, and they also showed the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo.

TL;DR: In this article, RNA interference was applied to inhibit production of HBV replicative intermediates in cell culture and in immunocompetent and immunodeficient mice transfected with an HBV plasmid.

TL;DR: It is demonstrated that siRNA modified with 2'-fluoro (2'-F) pyrimidines are functional in cell culture and have a greatly increased stability and a prolonged half-life in human plasma as compared to 2'-OH containing siRNAs.

TL;DR: Increased the silencing activity and specificity of aptamer-siRNA chimeras by incorporating modifications that enable more efficient processing of the siRNA by the cellular machinery and resulted in pronounced regression of PSMA-expressing tumors in athymic mice after systemic administration.

TL;DR: The data suggest miRNAs can contribute to changes in macrophage gene expression that occur in different exogenous activating conditions, and can be at least partially explained by repression of TNFAIP3, a negative regulator of NF-κB signaling.