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Antoninus Soosaipillai
Researcher at Mount Sinai Hospital, Toronto
Publications - 103
Citations - 4499
Antoninus Soosaipillai is an academic researcher from Mount Sinai Hospital, Toronto. The author has contributed to research in topics: Kallikrein & Cancer. The author has an hindex of 40, co-authored 93 publications receiving 4191 citations. Previous affiliations of Antoninus Soosaipillai include Lunenfeld-Tanenbaum Research Institute & Mount Sinai Hospital.
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Journal ArticleDOI
Human Kallikrein 6 (hK6): A New Potential Serum Biomarker for Diagnosis and Prognosis of Ovarian Carcinoma
Eleftherios P. Diamandis,Andreas Scorilas,S. Fracchioli,Marleen Van Gramberen,Henk W.A. de Bruijn,Alfthan Henrik,Antoninus Soosaipillai,Linda Grass,George M. Yousef,Ulf-Håkan Stenman,Marco Massobrio,Ate G.J. van der Zee,Ignace Vergote,Dionyssios Katsaros +13 more
TL;DR: Serum hK6 concentration seems to be a new biomarker for ovarian carcinoma and may have value for disease diagnosis and prognosis and is a powerful predictor of disease-free and overall survival in both univariate and multivariate analyses.
Journal ArticleDOI
Human kallikrein 6 (zyme/protease M/neurosin): a new serum biomarker of ovarian carcinoma.
Eleftherios P. Diamandis,George M. Yousef,George M. Yousef,Antoninus Soosaipillai,Peter S. Bunting,Peter S. Bunting +5 more
TL;DR: The first report describing significant elevations of hK6 concentration in serum of ovarian cancer patients is described, suggesting that hK 6 may represent a potential new biomarker for diagnosis and monitoring of ovarian carcinoma.
Journal Article
Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma.
Eleftherios P. Diamandis,Akira Okui,Shinichii Mitsui,Liu-Ying Luo,Antoninus Soosaipillai,Linda Grass,Terukazu Nakamura,David Howarth,Nozomi Yamaguchi +8 more
TL;DR: The aim was to develop immunological reagents and assays for measuring hK11 and examine if the concentration of this kallikrein is altered in disease states and develop an immunofluorometric procedure with high sensitivity and specificity.
Journal Article
Parallel Overexpression of Seven Kallikrein Genes in Ovarian Cancer
George M. Yousef,Mary-Ellen Polymeris,George M. Yacoub,Andreas Scorilas,Antoninus Soosaipillai,Cynthia Popalis,S. Fracchioli,Dionyssios Katsaros,Eleftherios P. Diamandis +8 more
TL;DR: The expression of five KLKs showed a strong degree of correlation at the protein level, suggesting the existence of a common mechanism or pathway that controls the expression of this group of adjacent genes during ovarian cancer progression.
Journal Article
Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer.
George M. Yousef,Mary Ellen Polymeris,Linda Grass,Antoninus Soosaipillai,Pak Cheung Chan,Andreas Scorilas,Carla A. Borgoño,Nadia Harbeck,Barbara Schmalfeldt,Julia Dorn,Manfred Schmitt,Eleftherios P. Diamandis +11 more
TL;DR: The preliminary data indicate that hK5 is a potential biomarker in patients with ovarian and breast cancer, and a sandwich-type microplate immunoassay (ELISA) was developed using these antibodies, coupled with a time-resolved fluorometric detection technique.